Macrolides: From Toxins to Therapeutics
- PMID: 34065929
- PMCID: PMC8150546
- DOI: 10.3390/toxins13050347
Macrolides: From Toxins to Therapeutics
Abstract
Macrolides are a diverse class of hydrophobic compounds characterized by a macrocyclic lactone ring and distinguished by variable side chains/groups. Some of the most well characterized macrolides are toxins produced by marine bacteria, sea sponges, and other species. Many marine macrolide toxins act as biomimetic molecules to natural actin-binding proteins, affecting actin polymerization, while other toxins act on different cytoskeletal components. The disruption of natural cytoskeletal processes affects cell motility and cytokinesis, and can result in cellular death. While many macrolides are toxic in nature, others have been shown to display therapeutic properties. Indeed, some of the most well known antibiotic compounds, including erythromycin, are macrolides. In addition to antibiotic properties, macrolides have been shown to display antiviral, antiparasitic, antifungal, and immunosuppressive actions. Here, we review each functional class of macrolides for their common structures, mechanisms of action, pharmacology, and human cellular targets.
Keywords: antibiotic; antifungal; antiparasitic; antiviral; immunosuppressant; macrolide; toxin.
Conflict of interest statement
The authors declare no conflict of interest.
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References
-
- Bryskier A., Bergogne-Bérézin E. Antimicrobial Agents. American Society of Microbiology; Washington, DC, USA: 2005. Macrolides. - DOI
-
- Guenin-Macé L., Ruf M.-T., Pluschke G., Demangel C. Mycolactone: More than Just a Cytotoxin. In: Pluschke G., Röltgen K., editors. Buruli Ulcer: Mycobacterium Ulcerans Disease. Springer International Publishing; Cham, Switzerland: 2019. pp. 117–134. - DOI
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