Effects of linkage on rates of molecular evolution
- PMID: 3413105
- PMCID: PMC281982
- DOI: 10.1073/pnas.85.17.6414
Effects of linkage on rates of molecular evolution
Abstract
When an advantageous mutation is fixed in a population by selection, a closely linked selectively neutral or mildly detrimental mutation may "hitchhike" to fixation along with it. It has been suggested that hitchhiking might increase the rate of molecular evolution. Computer simulations and a mathematical argument show that complete linkage to either advantageous or deleterious mutations does not affect the substitution of selectively neutral mutations. However, the simulations show that linkage to selected background mutations decreases the rate of fixation of advantageous mutations and increases the rate of fixation of detrimental mutations. This is true whether the linked background mutations are advantageous or detrimental, and it verifies and extends previous observations that linkage tends to reduce the effects of selection on evolution. These results can be interpreted in terms of the Hill-Robertson effect: a locus linked to another locus under selection experiences a reduction in effective population size. The interpretation of differences in evolutionary rates between different genomes or different regions of a genome may be confounded by the effects of strong linkage and selection. Recombination is expected to reduce the overall rate of molecular evolution while enhancing the rate of adaptive evolution.
Similar articles
-
Effect of epistasis and linkage on fixation probability in three-locus models: an ancestral recombination-selection graph approach.Theor Popul Biol. 2012 Sep;82(2):131-45. doi: 10.1016/j.tpb.2012.05.002. Epub 2012 May 23. Theor Popul Biol. 2012. PMID: 22634384
-
Recombination and hitchhiking of deleterious alleles.Evolution. 2011 Sep;65(9):2421-34. doi: 10.1111/j.1558-5646.2011.01311.x. Epub 2011 Apr 26. Evolution. 2011. PMID: 21884046
-
Local effects of limited recombination: historical perspective and consequences for population estimates of adaptive evolution.J Hered. 2010 Mar-Apr;101 Suppl 1:S127-34. doi: 10.1093/jhered/esq012. J Hered. 2010. PMID: 20421321 Review.
-
The role of advantageous mutations in enhancing the evolution of a recombination modifier.Genetics. 2010 Apr;184(4):1153-64. doi: 10.1534/genetics.109.112920. Epub 2010 Feb 5. Genetics. 2010. PMID: 20139345 Free PMC article.
-
The Hill-Robertson effect: evolutionary consequences of weak selection and linkage in finite populations.Heredity (Edinb). 2008 Jan;100(1):19-31. doi: 10.1038/sj.hdy.6801059. Epub 2007 Sep 19. Heredity (Edinb). 2008. PMID: 17878920 Review.
Cited by
-
Population genetic considerations regarding the interpretation of within-patient SARS-CoV-2 polymorphism data.Nat Commun. 2024 Apr 16;15(1):3240. doi: 10.1038/s41467-024-46261-4. Nat Commun. 2024. PMID: 38627371 Free PMC article. No abstract available.
-
Linked selection and the evolution of altruism in family-structured populations.Ecol Evol. 2024 Feb 16;14(2):e10980. doi: 10.1002/ece3.10980. eCollection 2024 Feb. Ecol Evol. 2024. PMID: 38371869 Free PMC article.
-
Shared evolutionary processes shape landscapes of genomic variation in the great apes.Genetics. 2024 Apr 3;226(4):iyae006. doi: 10.1093/genetics/iyae006. Genetics. 2024. PMID: 38242701 Free PMC article.
-
Evaluating power to detect recurrent selective sweeps under increasingly realistic evolutionary null models.bioRxiv [Preprint]. 2023 Jun 15:2023.06.15.545166. doi: 10.1101/2023.06.15.545166. bioRxiv. 2023. Update in: Evolution. 2023 Oct 3;77(10):2113-2127. doi: 10.1093/evolut/qpad120. PMID: 37398347 Free PMC article. Updated. Preprint.
-
Evaluating power to detect recurrent selective sweeps under increasingly realistic evolutionary null models.Evolution. 2023 Oct 3;77(10):2113-2127. doi: 10.1093/evolut/qpad120. Evolution. 2023. PMID: 37395482 Free PMC article.
References
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources