Suggested treatment of serious complications to COVID-19 vaccination with IdeS, a bacterial antibody-cleaving enzyme

doi:10.1111/jth.15433

Comment

. 2021 Sep;19(9):2363-2364.

doi: 10.1111/jth.15433. Epub 2021 Jul 9.

Suggested treatment of serious complications to COVID-19 vaccination with IdeS, a bacterial antibody-cleaving enzyme

Fredrik Kahn¹, Oonagh Shannon¹, Lars Björck¹

Affiliations

PMID: 34165239
PMCID: PMC8420602
DOI: 10.1111/jth.15433

Comment

Suggested treatment of serious complications to COVID-19 vaccination with IdeS, a bacterial antibody-cleaving enzyme

Fredrik Kahn et al. J Thromb Haemost. 2021 Sep.

. 2021 Sep;19(9):2363-2364.

doi: 10.1111/jth.15433. Epub 2021 Jul 9.

Authors

Fredrik Kahn¹, Oonagh Shannon¹, Lars Björck¹

Affiliation

¹ Clinical Sciences, Lund University, Lund, Sweden.

PMID: 34165239
PMCID: PMC8420602
DOI: 10.1111/jth.15433

No abstract available

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Comment in

Reply to the letter entitled "Suggested treatment of serious complications to Covid-19 vaccination with IdeS, a bacterial antibody-cleaving enzyme".
Gruel Y, Vayne C, Rollin J, Pouplard C. Gruel Y, et al. J Thromb Haemost. 2021 Oct;19(10):2632. doi: 10.1111/jth.15465. Epub 2021 Jul 30. J Thromb Haemost. 2021. PMID: 34331369 Free PMC article. No abstract available.

Comment on

Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination.
Greinacher A, Thiele T, Warkentin TE, Weisser K, Kyrle PA, Eichinger S. Greinacher A, et al. N Engl J Med. 2021 Jun 3;384(22):2092-2101. doi: 10.1056/NEJMoa2104840. Epub 2021 Apr 9. N Engl J Med. 2021. PMID: 33835769 Free PMC article.
Thrombocytopenia with acute ischemic stroke and bleeding in a patient newly vaccinated with an adenoviral vector-based COVID-19 vaccine.
Blauenfeldt RA, Kristensen SR, Ernstsen SL, Kristensen CCH, Simonsen CZ, Hvas AM. Blauenfeldt RA, et al. J Thromb Haemost. 2021 Jul;19(7):1771-1775. doi: 10.1111/jth.15347. Epub 2021 May 5. J Thromb Haemost. 2021. PMID: 33877737 Free PMC article.
Evaluation of laboratory assays for anti-platelet factor 4 antibodies after ChAdOx1 nCOV-19 vaccination.
Platton S, Bartlett A, MacCallum P, Makris M, McDonald V, Singh D, Scully M, Pavord S. Platton S, et al. J Thromb Haemost. 2021 Aug;19(8):2007-2013. doi: 10.1111/jth.15362. Epub 2021 Jul 5. J Thromb Haemost. 2021. PMID: 33973336 Free PMC article.

Cited by

Anchoring IgG-degrading enzymes to the surface of platelets selectively neutralizes antiplatelet antibodies.
Lynch DR, Stringham EN, Zhang B, Balbin-Cuesta G, Curtis BR, Palumbo JS, Greineder CF, Tourdot BE. Lynch DR, et al. Blood Adv. 2022 Aug 9;6(15):4645-4656. doi: 10.1182/bloodadvances.2022007195. Blood Adv. 2022. PMID: 35737875 Free PMC article.
Reply to the letter entitled "Suggested treatment of serious complications to Covid-19 vaccination with IdeS, a bacterial antibody-cleaving enzyme".
Gruel Y, Vayne C, Rollin J, Pouplard C. Gruel Y, et al. J Thromb Haemost. 2021 Oct;19(10):2632. doi: 10.1111/jth.15465. Epub 2021 Jul 30. J Thromb Haemost. 2021. PMID: 34331369 Free PMC article. No abstract available.
Thrombocytopenia with acute ischemic stroke and bleeding in a patient newly vaccinated with an adenoviral vector-based COVID-19 vaccine: COMMENT from Gruel et al.: RESPONSE from Kahn et al.
Kahn F, Shannon O, Björck L. Kahn F, et al. J Thromb Haemost. 2021 Oct;19(10):2633. doi: 10.1111/jth.15467. Epub 2021 Aug 5. J Thromb Haemost. 2021. PMID: 34273222 Free PMC article. No abstract available.

References

1. Blauenfeldt R.A., Kristensen S.R., Ernstsen S.L., Kristensen C.C.H., Simonsen C.Z., Hvas A.‐.M. Thrombocytopenia with acute ischemic stroke and bleeding in a patient newly vaccinated with an adenoviral vector‐based COVID‐19 vaccine. J Thromb Haemost. 2021;19(7):1771–1775. doi: 10.1111/jth.15347. - DOI - PMC - PubMed
1. Greinacher A., Thiele T., Warkentin T.E., Weisser K., Kyrle P.A., Eichinger S. Thrombotic Thrombocytopenia after ChAdOx1 nCov‐19 Vaccination. New Engl J Med. 2021;384:2092–2101. doi: 10.1056/NEJMoa2104840. - DOI - PMC - PubMed
1. Platton S., Bartlett A., MacCallum P., et al. Evaluation of laboratory assays for anti‐Platelet Factor 4 antibodies after ChAdOx1 nCOV‐19 vaccination. J Thromb Haemost. 2021 doi: 10.1111/jth.15362. - DOI - PMC - PubMed
1. Shannon O., Hertzén E., Norrby‐Teglund A., Mörgelin M., Sjöbring U., Björck L. Severe streptococcal infection is associated with M protein‐induced platelet activation and thrombus formation. Mol Microbiol. 2007;65:1147–1157. - PubMed
1. von Pawel‐Rammingen U., Johansson B.P., Björck L. IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G. EMBO J. 2002;21:1607–1615. - PMC - PubMed

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[1] Blauenfeldt R.A., Kristensen S.R., Ernstsen S.L., Kristensen C.C.H., Simonsen C.Z., Hvas A.‐.M. Thrombocytopenia with acute ischemic stroke and bleeding in a patient newly vaccinated with an adenoviral vector‐based COVID‐19 vaccine. J Thromb Haemost. 2021;19(7):1771–1775. doi: 10.1111/jth.15347. - DOI - PMC - PubMed

[2] Blauenfeldt R.A., Kristensen S.R., Ernstsen S.L., Kristensen C.C.H., Simonsen C.Z., Hvas A.‐.M. Thrombocytopenia with acute ischemic stroke and bleeding in a patient newly vaccinated with an adenoviral vector‐based COVID‐19 vaccine. J Thromb Haemost. 2021;19(7):1771–1775. doi: 10.1111/jth.15347. - DOI - PMC - PubMed

[3] Greinacher A., Thiele T., Warkentin T.E., Weisser K., Kyrle P.A., Eichinger S. Thrombotic Thrombocytopenia after ChAdOx1 nCov‐19 Vaccination. New Engl J Med. 2021;384:2092–2101. doi: 10.1056/NEJMoa2104840. - DOI - PMC - PubMed

[4] Greinacher A., Thiele T., Warkentin T.E., Weisser K., Kyrle P.A., Eichinger S. Thrombotic Thrombocytopenia after ChAdOx1 nCov‐19 Vaccination. New Engl J Med. 2021;384:2092–2101. doi: 10.1056/NEJMoa2104840. - DOI - PMC - PubMed

[5] Platton S., Bartlett A., MacCallum P., et al. Evaluation of laboratory assays for anti‐Platelet Factor 4 antibodies after ChAdOx1 nCOV‐19 vaccination. J Thromb Haemost. 2021 doi: 10.1111/jth.15362. - DOI - PMC - PubMed

[6] Platton S., Bartlett A., MacCallum P., et al. Evaluation of laboratory assays for anti‐Platelet Factor 4 antibodies after ChAdOx1 nCOV‐19 vaccination. J Thromb Haemost. 2021 doi: 10.1111/jth.15362. - DOI - PMC - PubMed

[7] Shannon O., Hertzén E., Norrby‐Teglund A., Mörgelin M., Sjöbring U., Björck L. Severe streptococcal infection is associated with M protein‐induced platelet activation and thrombus formation. Mol Microbiol. 2007;65:1147–1157. - PubMed

[8] Shannon O., Hertzén E., Norrby‐Teglund A., Mörgelin M., Sjöbring U., Björck L. Severe streptococcal infection is associated with M protein‐induced platelet activation and thrombus formation. Mol Microbiol. 2007;65:1147–1157. - PubMed

[9] von Pawel‐Rammingen U., Johansson B.P., Björck L. IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G. EMBO J. 2002;21:1607–1615. - PMC - PubMed

[10] von Pawel‐Rammingen U., Johansson B.P., Björck L. IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G. EMBO J. 2002;21:1607–1615. - PMC - PubMed

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Suggested treatment of serious complications to COVID-19 vaccination with IdeS, a bacterial antibody-cleaving enzyme

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Suggested treatment of serious complications to COVID-19 vaccination with IdeS, a bacterial antibody-cleaving enzyme

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