Hyperglycemia Drives Stent Restenosis in STEMI Patients

doi:10.2337/dc21-0939

. 2021 Nov;44(11):e192-e193.

doi: 10.2337/dc21-0939. Epub 2021 Sep 16.

Hyperglycemia Drives Stent Restenosis in STEMI Patients

Pasquale Mone^{1

2

3}, Jessica Gambardella^{4

5

6}, Fabio Minicucci⁷, Angela Lombardi⁴, Ciro Mauro⁷, Gaetano Santulli^{1

5

6}

Affiliations

¹ Department of Medicine, Einstein-Mount Sinai Diabetes Research Center, and Fleischer Institute for Diabetes and Metabolism, New York, NY pasquale.mone@unicampania.it gsantulli001@gmail.com.
² Department of Mental and Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli," Naples, Italy.
³ Azienda Sanitaria Locale Avellino, Avellino, Italy.
⁴ Department of Medicine, Einstein-Mount Sinai Diabetes Research Center, and Fleischer Institute for Diabetes and Metabolism, New York, NY.
⁵ Department of Molecular Pharmacology, Wilf Family Cardiovascular Research Institute, and Institute for Aging Research, Albert Einstein College of Medicine, New York, NY.
⁶ International Translational Research and Medical Education Consortium and Department of Advanced Biomedical Sciences, "Federico II" University, Naples, Italy.
⁷ Department of Emergency, "Antonio Cardarelli" Hospital, Naples, Italy.

PMID: 34531311
PMCID: PMC8546275
DOI: 10.2337/dc21-0939

Hyperglycemia Drives Stent Restenosis in STEMI Patients

Pasquale Mone et al. Diabetes Care. 2021 Nov.

. 2021 Nov;44(11):e192-e193.

doi: 10.2337/dc21-0939. Epub 2021 Sep 16.

Authors

Pasquale Mone^{1

2

3}, Jessica Gambardella^{4

5

6}, Fabio Minicucci⁷, Angela Lombardi⁴, Ciro Mauro⁷, Gaetano Santulli^{1

5

6}

Affiliations

¹ Department of Medicine, Einstein-Mount Sinai Diabetes Research Center, and Fleischer Institute for Diabetes and Metabolism, New York, NY pasquale.mone@unicampania.it gsantulli001@gmail.com.
² Department of Mental and Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli," Naples, Italy.
³ Azienda Sanitaria Locale Avellino, Avellino, Italy.
⁴ Department of Medicine, Einstein-Mount Sinai Diabetes Research Center, and Fleischer Institute for Diabetes and Metabolism, New York, NY.
⁵ Department of Molecular Pharmacology, Wilf Family Cardiovascular Research Institute, and Institute for Aging Research, Albert Einstein College of Medicine, New York, NY.
⁶ International Translational Research and Medical Education Consortium and Department of Advanced Biomedical Sciences, "Federico II" University, Naples, Italy.
⁷ Department of Emergency, "Antonio Cardarelli" Hospital, Naples, Italy.

PMID: 34531311
PMCID: PMC8546275
DOI: 10.2337/dc21-0939

No abstract available

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Figures

**Figure 1**
A: Kaplan-Meier curves assessing the cumulative risk of restenosis in patients with ST-elevation myocardial infarction (STEMI) from hospital admission to 365 days; patients were subdivided into three groups: normoglycemic (NG) subjects, patients without diabetes mellitus (DM) but with hyperglycemia HG (HG-non-DM), and patients with both HG and DM (HG-DM). B: Multivariate Cox regression analysis in STEMI HG-non-DM patients. BMI, body mass index; CI, confidence interval; DBP, diastolic blood pressure; HbA_1c, hemoglobin A_1c (glycated hemoglobin); HR, hazard ratio; LDL, low-density lipoprotein; SBP, systolic blood pressure.

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References

1. Zarich SW, Nesto RW. Implications and treatment of acute hyperglycemia in the setting of acute myocardial infarction. Circulation 2007;115:e436–e439 - PubMed
1. Marfella R, Sasso FC, Siniscalchi M, et al. . Peri-procedural tight glycemic control during early percutaneous coronary intervention is associated with a lower rate of in-stent restenosis in patients with acute ST-elevation myocardial infarction. J Clin Endocrinol Metab 2012;97:2862–2871 - PubMed
1. American Diabetes Association . 15. Diabetes care in the hospital: Standards of Medical Care in Diabetes–2021. Diabetes Care 2021;44(Suppl. 1):S211–S220 - PubMed
1. Santulli G, Wronska A, Uryu K, et al. . A selective microRNA-based strategy inhibits restenosis while preserving endothelial function. J Clin Invest 2014;124:4102–4114 - PMC - PubMed
1. Roberts GW, Quinn SJ, Valentine N, et al. . Relative hyperglycemia, a marker of critical illness: Introducing the stress hyperglycemia ratio. J Clin Endocrinol Metab 2015;100:4490–4497 - PubMed

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[1] Zarich SW, Nesto RW. Implications and treatment of acute hyperglycemia in the setting of acute myocardial infarction. Circulation 2007;115:e436–e439 - PubMed

[2] Zarich SW, Nesto RW. Implications and treatment of acute hyperglycemia in the setting of acute myocardial infarction. Circulation 2007;115:e436–e439 - PubMed

[3] Marfella R, Sasso FC, Siniscalchi M, et al. . Peri-procedural tight glycemic control during early percutaneous coronary intervention is associated with a lower rate of in-stent restenosis in patients with acute ST-elevation myocardial infarction. J Clin Endocrinol Metab 2012;97:2862–2871 - PubMed

[4] Marfella R, Sasso FC, Siniscalchi M, et al. . Peri-procedural tight glycemic control during early percutaneous coronary intervention is associated with a lower rate of in-stent restenosis in patients with acute ST-elevation myocardial infarction. J Clin Endocrinol Metab 2012;97:2862–2871 - PubMed

[5] American Diabetes Association . 15. Diabetes care in the hospital: Standards of Medical Care in Diabetes–2021. Diabetes Care 2021;44(Suppl. 1):S211–S220 - PubMed

[6] American Diabetes Association . 15. Diabetes care in the hospital: Standards of Medical Care in Diabetes–2021. Diabetes Care 2021;44(Suppl. 1):S211–S220 - PubMed

[7] Santulli G, Wronska A, Uryu K, et al. . A selective microRNA-based strategy inhibits restenosis while preserving endothelial function. J Clin Invest 2014;124:4102–4114 - PMC - PubMed

[8] Santulli G, Wronska A, Uryu K, et al. . A selective microRNA-based strategy inhibits restenosis while preserving endothelial function. J Clin Invest 2014;124:4102–4114 - PMC - PubMed

[9] Roberts GW, Quinn SJ, Valentine N, et al. . Relative hyperglycemia, a marker of critical illness: Introducing the stress hyperglycemia ratio. J Clin Endocrinol Metab 2015;100:4490–4497 - PubMed

[10] Roberts GW, Quinn SJ, Valentine N, et al. . Relative hyperglycemia, a marker of critical illness: Introducing the stress hyperglycemia ratio. J Clin Endocrinol Metab 2015;100:4490–4497 - PubMed

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Hyperglycemia Drives Stent Restenosis in STEMI Patients

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Hyperglycemia Drives Stent Restenosis in STEMI Patients

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