doi: 10.1073/pnas.83.2.419.
Chromosomal localization of the human apolipoprotein B gene and detection of homologous RNA in monkey intestine
- PMID: 3455779
- PMCID: PMC322870
- DOI: 10.1073/pnas.83.2.419
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Chromosomal localization of the human apolipoprotein B gene and detection of homologous RNA in monkey intestine
Proc Natl Acad Sci U S A.
1986 Jan.
Abstract
A cDNA clone of the human apolipoprotein B-100 was used as a hybridization probe to detect homologous sequences in both flow-sorted and in situ metaphase chromosomes. The results indicate that the gene encoding this protein is on the distal end of the short arm of chromosome 2 (2p23-2p24). RNA isolated from monkey small intestine contained sequences (6.5 and 18 kilobases) homologous to the cDNA of apolipoprotein B-100. These results are consistent with the hypothesis that one gene codes for both the intestinal (B-48) and the hepatic (B-100) forms.
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