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Review
. 2021;5(4):314-326.
doi: 10.1007/s41664-021-00198-5. Epub 2021 Oct 4.

Diagnostic Techniques for COVID-19: A Mini-review of Early Diagnostic Methods

Gao-Pan Dong  1   2 , Xiu-Juan Guo  1   2 , Ying-Ai Sun  1 , Zheng Zhang  1 , Lu-Pei Du  1 , Min-Yong Li  1
Affiliations
Review

Diagnostic Techniques for COVID-19: A Mini-review of Early Diagnostic Methods

Gao-Pan Dong et al. J Anal Test. 2021.

Abstract

The outbreak of severe pneumonia at the end of 2019 was proved to be caused by the SARS-CoV-2 virus spreading out the world. And COVID-19 spread rapidly through a terrible transmission way by human-to-human, which led to many suspected cases waiting to be diagnosed and huge daily samples needed to be tested by an effective and rapid detection method. With an increasing number of COVID-19 infections, medical pressure is severe. Therefore, more efficient and accurate diagnosis methods were keen urgently established. In this review, we summarized several methods that can rapidly and sensitively identify COVID-19; some of them are widely used as the diagnostic techniques for SARS-CoV-2 in various countries, some diagnostic technologies refer to SARS (Severe Acute Respiratory Syndrome) or/and MERS (Middle East Respiratory Syndrome) detection, which may provide potential diagnosis ideas.

Keywords: COVID-19; Diagnostic approach; Rapid and accurate methods; SARS-CoV-2 virus; Severe respiratory disease.

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Conflict of interest statement

Conflict of interestThe authors declare no conflicts of interest.

Figures

Fig. 1
Fig. 1
Structure of SARS-CoV-2. Source cited with permission from Ref. [8]. 2020, Cell
Fig. 2
Fig. 2
The progress of the nucleic acid test, RT-qPCR. Obtaining permission from Ref. [29]. 2021, Talanta
Fig. 3
Fig. 3
Group testing designs. a, b The test results used to identify positive samples; c estimate the prevalence in the community. The figure reproduced with permission from Ref. [30]. 2021, Sci Transl Med
Fig. 4
Fig. 4
Conventional antibody tests of COVID-19 by ELISA. Obtaining permission from Ref. [29]. 2021, Talanta
Fig. 5
Fig. 5
The schematic diagram of FET based biosensor. Reproduced with permission from Ref. [98]. 2020, ACS Nano
Fig. 6
Fig. 6
The schematic diagram of GC-FP biosensor chips, and the principle of assessing the blood samples with the antibody of COVID-19. Reproduced with permission from Ref. [103]. 2021, Biosens Bioelectron
See this image and copyright information in PMC

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