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. 2022 Jan 4:8:671667.
doi: 10.3389/fmed.2021.671667. eCollection 2021.

Serum Lactate Dehydrogenase Level as a Prognostic Factor for COVID-19: A Retrospective Study Based on a Large Sample Size

Yihui Huang  1 , Liang Guo  1 , Jiwei Chen  2 , Meng Wu  3 , Chao Zhang  4 , Zeming Liu  5 , Jinpeng Li  2 , Kun Li  6 , Zhongwei Xiong  7 , Qian Wu  7 , Zhengwei Li  7 , Kuan Luo  8 , Weiwei Yuan  9 , Xiaohui Wu  7
Affiliations

Serum Lactate Dehydrogenase Level as a Prognostic Factor for COVID-19: A Retrospective Study Based on a Large Sample Size

Yihui Huang et al. Front Med (Lausanne). .

Abstract

Background: In this study, we investigated the relationship between serum lactate dehydrogenase (LDH) level and disease progression and prognosis of patients with COVID-19. Methods: We retrospectively reviewed the information of 1,751 patients with COVID-19 from Leishenshan Hospital in Wuhan, China. Univariate and multivariate Cox regression analyses as well as Logistics regression analyses, and Kaplan-Meier curves were used to determine the association between LDH levels and the prognosis of COVID-19 patients. Results: LDH was an independent risk factor for in-hospital death no matter it was taken as classified variable and continuous variable (all P = 0.001) but not for severe or critical illness status. The Kaplan-Meier curves for LDH level showed that an elevated level of LDH was associated with in-hospital death. Conclusions: In patients with COVID-19, the increased LDH level is associated with a higher risk of negative clinical prognosis and higher mortality. This will provide a reference for clinicians and researchers to understand, diagnose, and treat patients with COVID-19. Further prospective studies with larger sample sizes are needed to verify these findings.

Keywords: COVID-19; Leishenshan Hospital; SARS-CoV-2; lactate dehydrogenase (LDH); prognostic factor.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The Kaplan-Meier curves for the survival of COVID-19 patients in different LDH level (normal group, decreased group, evaluated group).
Figure 2
Figure 2
The Kaplan-Meier curves for the survival of COVID-19 patients in different LDH level (normal or decreased group, evaluated group).
Figure 3
Figure 3
Curve fitting analysis for all the COVID-19 patients (A–C), LDH normal or decreased group (D–F) and LDH evaluated group (G–I).
See this image and copyright information in PMC

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