Association between environmental toxic metals, arsenic and polycyclic aromatic hydrocarbons and chronic obstructive pulmonary disease in the US adult population
- PMID: 35303226
- DOI: 10.1007/s11356-022-19695-w
Association between environmental toxic metals, arsenic and polycyclic aromatic hydrocarbons and chronic obstructive pulmonary disease in the US adult population
Abstract
Associations between environmental metals and chemicals and adverse human health effects have emerged recently, but the links among environmental metals and respiratory diseases are less studied. The aim of this study was to assess 14 urinary metals (cadmium, barium, cobalt, molybdenum, mercury, cesium, manganese, antimony, lead, tin, strontium, tungsten, thallium, and uranium), seven species of arsenic (arsenous acid, arsenic acid, arsenobetaine, arsenocholine, dimethylarsinic acid, monomethylarsonic acid, and total arsenic) and seven polycyclic aromatic hydrocarbon (PAH) (1-hydroxynaphthalene, 2-hydroxynaphthalene, 3-hydroxyfluorene, 2-hydroxyfluorene, 1-hydroxyphenanthrene, 1-hydroxypyrene, 2 & 3-hydroxyphenanthrene) compounds' concentrations in urine and the correlation with chronic obstructive pulmonary disease (COPD) in the adult US population. A cross-sectional analysis using the 2013-2014 and 2015-2016 National Health and Nutrition Examination Survey (NHANES) dataset was conducted. Self-questionnaires related to COPD criteria were used to identify the COPD cases. The correlation between urinary metals and PAH compounds and COPD was calculated. The total study population analyzed included 2885 adults aged 20 years and older. Seven types of urinary PAHs including 1-hydroxynaphthalene [odds ratio (OR): 1.832, 95% confidence interval (CI): 1.210, 2.775], 2-hydroxynaphthalene [OR: 3.361, 95% CI: 1.519, 7.440], 3-hydroxyfluorene [OR: 2.641, 95% CI: 1.381, 5.053], 2-hydroxyfluorene [OR: 3.628, 95% CI: 1.754, 7.506], 1-hydroxyphenanthrene [OR: 2.864, 95% CI: 1.307, 6.277], 1-hydroxypyrene [OR: 4.949, 95% CI: 2.540, 9.643] and 2 & 3-hydroxyphenanthrene [OR: 3.487, 95% CI: 1.382, 8.795] were positively associated with COPD. Urinary cadmium [OR: 12.382, 95% CI: 4.459, 34.383] and tin [OR: 1.743, 95% CI: 1.189, 2.555] showed positive associations with increased odds of COPD. The other types of urinary metals were not associated with COPD. The study observed that urinary PAHs, cadmium, and tin are significantly associated with COPD.
Keywords: COPD; Cadmium; NHANES; Polycyclic aromatic hydrocarbons; Tin.
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Similar articles
-
Urinary metals, arsenic, and polycyclic aromatic hydrocarbon exposure and risk of chronic bronchitis in the US adult population.Environ Sci Pollut Res Int. 2022 Oct;29(48):73480-73491. doi: 10.1007/s11356-022-20982-9. Epub 2022 May 27. Environ Sci Pollut Res Int. 2022. PMID: 35624372
-
Urinary Metals, Arsenic, and Polycyclic Aromatic Hydrocarbon Exposure and Risk of Self-reported Emphysema in the US Adult Population.Lung. 2022 Apr;200(2):237-249. doi: 10.1007/s00408-022-00518-1. Epub 2022 Feb 18. Lung. 2022. PMID: 35178625
-
Arsenic, polycyclic aromatic hydrocarbons, and metal exposure and risk assessment of stroke.Environ Sci Pollut Res Int. 2023 Aug;30(37):86973-86986. doi: 10.1007/s11356-023-28593-8. Epub 2023 Jul 6. Environ Sci Pollut Res Int. 2023. PMID: 37414997
-
Association of polycyclic aromatic hydrocarbons exposure with child neurodevelopment and adult emotional disorders: A meta-analysis study.Ecotoxicol Environ Saf. 2023 Apr 15;255:114770. doi: 10.1016/j.ecoenv.2023.114770. Epub 2023 Mar 15. Ecotoxicol Environ Saf. 2023. PMID: 36931089 Review.
-
A State-of-the-Science Review on Metal Biomarkers.Curr Environ Health Rep. 2023 Sep;10(3):215-249. doi: 10.1007/s40572-023-00402-x. Epub 2023 Jun 20. Curr Environ Health Rep. 2023. PMID: 37337116 Free PMC article. Review.
Cited by
-
Cobalt exposure and pulmonary function reduction in chronic obstructive pulmonary disease patients: the mediating role of club cell secretory protein.Respir Res. 2024 Aug 24;25(1):324. doi: 10.1186/s12931-024-02950-8. Respir Res. 2024. PMID: 39182083 Free PMC article.
-
Industrial impact on sustainable dairy farms: Essential elements, hazardous metals and polycyclic aromatic hydrocarbons in forage and cow's milk.Heliyon. 2023 Oct 16;9(10):e20977. doi: 10.1016/j.heliyon.2023.e20977. eCollection 2023 Oct. Heliyon. 2023. PMID: 37886788 Free PMC article.
-
Prevalence of associated factors on depression during COVID 19 in students in a minority serving institution: A cross sectional study.J Affect Disord Rep. 2023 Jul;13:100605. doi: 10.1016/j.jadr.2023.100605. Epub 2023 Jun 13. J Affect Disord Rep. 2023. PMID: 37333941 Free PMC article.
References
-
- Anthonisen NR, Connett JE, Kiley JP et al (1994) Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1. The Lung Health Study JAMA 272(19):1497–1505
-
- Asia Pacific COPD Roundtable Group (2005) Global initiative for chronic obstructive lung disease strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease: an Asia-Pacific perspective. Respirology 10(1):9–17. https://doi.org/10.1111/j.1440-1843.2005.00692.x - DOI
-
- Blanc PD, Torén K (2007) Occupation in chronic obstructive pulmonary disease and chronic bronchitis: an update. Int J Tuberc Lung Dis 11(3):251–257
-
- Błaszczyk E, Rogula-Kozłowska W, Klejnowski K, Fulara I, Mielżyńska-Švach D (2017) Polycyclic aromatic hydrocarbons bound to outdoor and indoor airborne particles (PM2.5) and their mutagenicity and carcinogenicity in Silesian kindergartens, Poland. Air Qual Atmos Health 10(3):389–400. https://doi.org/10.1007/s11869-016-0457-5
-
- Bousquet J, Kaltaev N (2007) Global surveillance, prevention and control of chronic respiratory diseases: a comprehensive approach. World Health Organization. https://apps.who.int/iris/handle/10665/43776
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical