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Randomized Controlled Trial
. 2022 Apr 30:11:giac031.
doi: 10.1093/gigascience/giac031.

Monash DaCRA fPET-fMRI: A dataset for comparison of radiotracer administration for high temporal resolution functional FDG-PET

Sharna D Jamadar  1   2   3 , Emma X Liang  1 , Shenjun Zhong  1   4 , Phillip G D Ward  1   3 , Alexandra Carey  1   5 , Richard McIntyre  1   5 , Zhaolin Chen  1   6 , Gary F Egan  1   2   3
Affiliations
Randomized Controlled Trial

Monash DaCRA fPET-fMRI: A dataset for comparison of radiotracer administration for high temporal resolution functional FDG-PET

Sharna D Jamadar et al. Gigascience. .

Abstract

Background: "Functional" [18F]-fluorodeoxyglucose positron emission tomography (FDG-fPET) is a new approach for measuring glucose uptake in the human brain. The goal of FDG-fPET is to maintain a constant plasma supply of radioactive FDG in order to track, with high temporal resolution, the dynamic uptake of glucose during neuronal activity that occurs in response to a task or at rest. FDG-fPET has most often been applied in simultaneous BOLD-fMRI/FDG-fPET (blood oxygenation level-dependent functional MRI fluorodeoxyglucose functional positron emission tomography) imaging. BOLD-fMRI/FDG-fPET provides the capability to image the 2 primary sources of energetic dynamics in the brain, the cerebrovascular haemodynamic response and cerebral glucose uptake.

Findings: In this Data Note, we describe an open access dataset, Monash DaCRA fPET-fMRI, which contrasts 3 radiotracer administration protocols for FDG-fPET: bolus, constant infusion, and hybrid bolus/infusion. Participants (n = 5 in each group) were randomly assigned to each radiotracer administration protocol and underwent simultaneous BOLD-fMRI/FDG-fPET scanning while viewing a flickering checkerboard. The bolus group received the full FDG dose in a standard bolus administration, the infusion group received the full FDG dose as a slow infusion over the duration of the scan, and the bolus-infusion group received 50% of the FDG dose as bolus and 50% as constant infusion. We validate the dataset by contrasting plasma radioactivity, grey matter mean uptake, and task-related activity in the visual cortex.

Conclusions: The Monash DaCRA fPET-fMRI dataset provides significant reuse value for researchers interested in the comparison of signal dynamics in fPET, and its relationship with fMRI task-evoked activity.

Keywords: blood oxygenation level–dependent functional magnetic resonance imaging; fluorodeoxyglucose positron emission tomography; functional MRI; functional PET; human neuroimaging; human neuroscience; radiotracer administration; simultaneous PET/MR.

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Figures

Figure 1:
Figure 1:
A. Hypothesized plasma radioactivity curves for the 3 administration protocols. Timing (i.e., signal peak and duration) is shown in comparison to the timing of the experimental protocol shown in panel B. We hypothesized that the bolus protocol would peak soon after administration and decline rather quickly thereafter, returning to baseline levels by the end of the scan. We predicted that the bolus protocol would show the largest overall peak signal. For the infusion protocol we hypothesized that radioactivity would be close to zero at the beginning of the scan, continuing to increase for the duration of the scan. For the bolus-infusion protocol, we predicted that the peak signal would occur around the same time as the bolus protocol but be of smaller magnitude. We expected the signal would decrease slightly but then remain at elevated levels for the duration of the scan. B, C. Experimental protocol. Checkerboard stimuli were presented in an embedded block design, with fast on/off periods (panel C) embedded within the longer “on” (panel B) periods. D. Predicted task-related timecourse for the fPET general linear model.
Figure 2:
Figure 2:
A. Plasma radioactivity curves (decay corrected) for (i) bolus administration, (ii) infusion administration, and (iii) bolus-infusion protocol. Black line shows mean radioactivity and grey lines show activity for individual participants. B. Mean grey matter signal across all voxels for each participant, calculated from reconstructed PET images prior to GLM analysis. Because the images are not quantified, units are arbitrary intensity. Grey lines indicate approximate area of task blocks (also refer to Fig. 1).
Figure 3:
Figure 3:
Group-level activation maps for task (Zcorr > 1.6) for (left) fMRI and (right) fPET; shown separately for (A) bolus group, (B) infusion group, (C) bolus-infusion group. Given that the fMRI protocol did not differ for the 3 groups we also show the group average fMRI across all 15 participants in panel D.
Figure 4:
Figure 4:
Percent signal change for 5 regions of interest for each administration method. Each column represents a single participant. Percent signal change is calculated as the β-regressor for all task blocks relative to rest blocks. L: left; R: right.
Figure 5:
Figure 5:
fPET results for Blocks 1, 2, 3 (top), 2, 3, 4 (middle), and 3, 4, 5 (bottom) for each administration protocol.
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