Urinary metals, arsenic, and polycyclic aromatic hydrocarbon exposure and risk of chronic bronchitis in the US adult population
- PMID: 35624372
- DOI: 10.1007/s11356-022-20982-9
Urinary metals, arsenic, and polycyclic aromatic hydrocarbon exposure and risk of chronic bronchitis in the US adult population
Abstract
Metals, arsenic, and polycyclic aromatic hydrocarbons (PAHs) have all been linked to respiratory diseases. Chronic bronchitis, which is a form of chronic obstructive pulmonary disease (COPD), is a major public health concern and source of morbidity and mortality in the US. The purpose of this study was to analyze the correlation of 14 urinary metals (antimony, barium, cadmium, cesium, cobalt, lead, manganese, mercury, molybdenum, strontium, thallium, tin, tungsten, uranium), seven species of arsenic, and seven forms of polycyclic aromatic hydrocarbon (PAH) concentrations and chronic bronchitis in the US population. A cross-sectional analysis using three datasets from the National Health and Nutrition Examination Survey (NHANES) between 2011 and 2016 in adults, aged 20 years and older. Chronic bronchitis was determined using a self-questionnaire from the NHANES dataset. A specialized weighted complex survey design analysis package was used to analyze NHANES data. Multivariate logistic regression models were used to determine the correlation between urinary metals, arsenic, PAHs, and chronic bronchitis. Models were adjusted for lifestyle and demographic factors. A total of 4186 participants were analyzed; 49.8% were female and 40.5% were non-Hispanic White. All seven types of PAHs showed a positive association with chronic bronchitis (1-hydroxynaphthalene odds ratio (OR): 1.559, 95% confidence interval (CI): 1.271-1.912; 2-hydroxynaphthalene OR: 2.498, 95% CI: 1.524-4.095; 3-hydroxyfluorene OR: 2.752, 95% CI: 2.100-3.608; 2-hydroxyfluorene OR: 3.461, 95% CI: 2.438-4.914; 1-hydroxyphenanthrene OR: 2.442, 95% CI: 1.515-3.937; 1-hydroxypyrene OR: 2.828, 95% CI: 1.728-4.629; 2 & 3-hydroxyphenanthrene OR: 3.690, 95% CI: 2.309-5.896). Of the metals, only urinary cadmium showed a statistically significant positive association (OR: 2.435, 95% CI: 1.401-4.235) with chronic bronchitis. No other metals or arsenic were correlated with chronic bronchitis. Seven forms of urinary PAHs, cadmium, and several demographic factors were associated with chronic bronchitis.
Keywords: Arsenic; Bronchitis; Cadmium; Chronic obstructive; Common; Polycyclic aromatic hydrocarbons; Pulmonary disease.
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Similar articles
-
Urinary Metals, Arsenic, and Polycyclic Aromatic Hydrocarbon Exposure and Risk of Self-reported Emphysema in the US Adult Population.Lung. 2022 Apr;200(2):237-249. doi: 10.1007/s00408-022-00518-1. Epub 2022 Feb 18. Lung. 2022. PMID: 35178625
-
Association between environmental toxic metals, arsenic and polycyclic aromatic hydrocarbons and chronic obstructive pulmonary disease in the US adult population.Environ Sci Pollut Res Int. 2022 Aug;29(36):54507-54517. doi: 10.1007/s11356-022-19695-w. Epub 2022 Mar 18. Environ Sci Pollut Res Int. 2022. PMID: 35303226
-
Urinary polycyclic aromatic hydrocarbon, arsenic, and metal exposure and correlation with emphysema in smokers.Toxicol Appl Pharmacol. 2022 Sep 1;450:116168. doi: 10.1016/j.taap.2022.116168. Epub 2022 Jul 13. Toxicol Appl Pharmacol. 2022. PMID: 35842137
-
A State-of-the-Science Review on Metal Biomarkers.Curr Environ Health Rep. 2023 Sep;10(3):215-249. doi: 10.1007/s40572-023-00402-x. Epub 2023 Jun 20. Curr Environ Health Rep. 2023. PMID: 37337116 Free PMC article. Review.
-
Association of polycyclic aromatic hydrocarbons exposure with child neurodevelopment and adult emotional disorders: A meta-analysis study.Ecotoxicol Environ Saf. 2023 Apr 15;255:114770. doi: 10.1016/j.ecoenv.2023.114770. Epub 2023 Mar 15. Ecotoxicol Environ Saf. 2023. PMID: 36931089 Review.
Cited by
-
Update of the risk assessment of inorganic arsenic in food.EFSA J. 2024 Jan 18;22(1):e8488. doi: 10.2903/j.efsa.2024.8488. eCollection 2024 Jan. EFSA J. 2024. PMID: 38239496 Free PMC article.
-
Association of chronic cough with exposure to polycyclic aromatic hydrocarbons in the US population.Heliyon. 2023 Dec 7;10(1):e23413. doi: 10.1016/j.heliyon.2023.e23413. eCollection 2024 Jan 15. Heliyon. 2023. PMID: 38173475 Free PMC article.
-
Systemic inflammation mediates environmental polycyclic aromatic hydrocarbons to increase chronic obstructive pulmonary disease risk in United States adults: a cross-sectional NHANES study.Front Public Health. 2023 Nov 21;11:1248812. doi: 10.3389/fpubh.2023.1248812. eCollection 2023. Front Public Health. 2023. PMID: 38074734 Free PMC article.
-
MicroRNAs as Potential Biomarkers of Environmental Exposure to Polycyclic Aromatic Hydrocarbons and Their Link with Inflammation and Lung Cancer.Int J Mol Sci. 2023 Nov 30;24(23):16984. doi: 10.3390/ijms242316984. Int J Mol Sci. 2023. PMID: 38069307 Free PMC article. Review.
-
Association Between C-Reactive Protein and Albumin Ratios and Risk of Mortality in Patients with Chronic Obstructive Pulmonary Disease.Int J Chron Obstruct Pulmon Dis. 2023 Oct 18;18:2289-2303. doi: 10.2147/COPD.S413912. eCollection 2023. Int J Chron Obstruct Pulmon Dis. 2023. PMID: 37873518 Free PMC article.
References
-
- Ali MK, Kim RY, Karim R et al (2017) Role of iron in the pathogenesis of respiratory disease. Int J Biochem Cell Biol 88:181–195. https://doi.org/10.1016/j.biocel.2017.05.003 - DOI
-
- Blanc PD, Torén K (2007) Occupation in chronic obstructive pulmonary disease and chronic bronchitis: an update. Int J Tuberc Lung Dis 11(3):251–257
-
- Błaszczyk E, Rogula-Kozłowska W, Klejnowski K, Fulara I, Mielżyńska-Švach D (2017) Polycyclic aromatic hydrocarbons bound to outdoor and indoor airborne particles (PM2.5) and their mutagenicity and carcinogenicity in Silesian kindergartens, Poland. Air Qual Atmos Health 10(3):389–400. https://doi.org/10.1007/s11869-016-0457-5 - DOI
-
- Briffa J, Sinagra E, Blundell R (2020) Heavy metal pollution in the environment and their toxicological effects on humans. Heliyon 6(9):e04691. https://doi.org/10.1016/j.heliyon.2020.e04691 - DOI
-
- Borgoño JM, Vicent P, Venturino H, Infante A (1977) Arsenic in the drinking water of the city of Antofagasta: epidemiological and clinical study before and after the installation of a treatment plant. Environ Health Perspect 19:103–105. https://doi.org/10.1289/ehp.19-1637404 - DOI
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical