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. 2022 Sep;43(9):5313-5322.
doi: 10.1007/s10072-022-06228-z. Epub 2022 Jun 23.

Neurocognitive correlates of numerical abilities in Parkinson's disease

Francesca Burgio  1 , Nicola Filippini  2 , Luca Weis  3 , Laura Danesin  2 , Giulio Ferrazzi  2 , Michela Garon  3 , Roberta Biundo  2   4   5 , Silvia Facchini  6 , Angelo Antonini  3   5   7 , Silvia Benavides-Varela  6   7   8 , Carlo Semenza  6   7 , Giorgio Arcara  2
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Neurocognitive correlates of numerical abilities in Parkinson's disease

Francesca Burgio et al. Neurol Sci. 2022 Sep.

Abstract

People with Parkinson's disease (PD) experience functional limitations early in the progression of the disease, showing, among other cognitive deficits, difficulties in mathematical abilities. The neural correlates of such abilities have been scarcely investigated in PD, and it is not known whether patients may exhibit difficulties only in formal numerical tasks (e.g., mental multiplications), or also in everyday activities involving numbers (i.e., informal numerical abilities such as time estimates). The present study investigated formal and informal numerical abilities in PD patients and explored their relationship with cortical and subcortical brain volume. We examined patients with PD and mild cognitive impairment (PD-MCI) and age-matched healthy controls (HCs) using the numerical activities of daily living (NADL) battery, assessing both scholastic numerical abilities (formal test), and the ability to use numbers in everyday life (informal test). We compared NADL performances in both groups. Within the PD group, we investigated the association between NADL and cortical and subcortical volumes using multiple linear regressions. The correlation with other cognitive tests was also explored. PD-MCI performed worse than HC in the formal NADL test. In PD-MCI patients, brain-behavior correlations showed two distinct patterns: cortical volumes correlated positively, while striatal volumes correlated negatively with NADL formal tasks. Both formal and informal tests correlated with measures of cognitive functioning. Our results suggest specific impairments in formal numerical abilities in PD-MCI, but not in everyday activities. While cortical atrophy is associated with worse performance, the negative correlations with subcortical regions suggest that their activation may reflect potential compensatory mechanisms.

Keywords: Activities of daily living; Basal ganglia; Cognitive impairment; MCI; Neuroimaging; Numerical abilities of daily living.

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