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Case Reports
. 2023 Mar 1;45(2):e294-e297.
doi: 10.1097/MPH.0000000000002509. Epub 2022 Jul 26.

Multifocal Infantile Hepatic Hemangiomas Complicated by Consumptive Hypothyroidism: The Benefits of Early Diagnosis and Treatment

Catarina Granjo Morais  1 , Inês Alves  2 , Janine Coelho  2 , Ana Teresa Vilares  3 , Maria Do Bom-Sucesso  2
Affiliations
Case Reports

Multifocal Infantile Hepatic Hemangiomas Complicated by Consumptive Hypothyroidism: The Benefits of Early Diagnosis and Treatment

Catarina Granjo Morais et al. J Pediatr Hematol Oncol. .

Abstract

Infantile hepatic hemangiomas (IHH) account for 12% of all childhood hepatic tumors. Most IHH are diagnosed within the first 6 months of life and involute spontaneously; however, some require medical treatment. The present report describes a case of multifocal IHH associated with subcutaneous and lingual hemangiomas, complicated by consumptive hypothyroidism and successfully managed with oral propranolol and thyroid replacement therapy, without documented adverse effects. Consumptive hypothyroidism is a rare complication of IHH, but suggestive of multifocal/diffuse subtypes. The authors intend to reinforce the importance of early referral to a Vascular Anomalies Center and treatment with propranolol in selected patients.

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Conflict of interest statement

The authors declare no conflict of interest.

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