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. 2022 Dec 5;11(23):7232.
doi: 10.3390/jcm11237232.

The Relationship between Serum Adiponectin, Urinary Albumin/Creatinine Ratio and Type 2 Diabetes: A Population-Based Cross-Sectional Study

Shoma Ono  1 , Satoru Mizushiri  1 , Yuki Nishiya  1 , Ayumi Tamura  1 , Kiho Hamaura  1 , Ryoma Ito  1 , Akihide Terada  1 , Jutaro Tanabe  1 , Miyuki Yanagimachi  1 , Kyi Mar Wai  2 , Kaori Sawada  2 , Kazushige Ihara  2 , Makoto Daimon  1
Affiliations

The Relationship between Serum Adiponectin, Urinary Albumin/Creatinine Ratio and Type 2 Diabetes: A Population-Based Cross-Sectional Study

Shoma Ono et al. J Clin Med. .

Abstract

The relationship between serum adiponectin concentration (S-Adipo) and various diseases, such as type 2 diabetes (T2D) is conflicting. We hypothesized that the extent of kidney damage in patients with T2D may be responsible for this inconsistency and, thus, examined association between S-Adipo and T2D after consideration for the extent of kidney damage present. Of the 1816 participants in the population-based Iwaki study of Japanese people, 1751 participants with a complete dataset were included. Multivariate logistic regression analyses revealed that low S-Adipo was independently associated with T2D (<0.001), as was high urinary albumin to creatinine ratio (uACR) (<0.001). Principal components analysis showed that the relative value of S-Adipo to uACR (adiponectin relative excess) was significantly associated with T2D (odds ratio: 0.49, p < 0.001). Receiver operating curve analyses revealed that an index of adiponectin relative excess the ratio of S-Adipo to uACR was superior to S-Adipo per se as a marker of T2D (area under the curve: 0.746 vs. 0.579, p < 0.001). This finding indicates that the relationship between S-Adipo and T2D should be evaluated according to the extent of kidney damage present and may warrant similar analyses of the relationships between S-Adipo and other medicalconditions, such as cardiovascular disease.

Keywords: cardiovascular disease; clinical application; serum adiponectin concentration; type 2 diabetes; urinary albumin to creatinine ratio.

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Conflict of interest statement

The authors have no competing interest relevant to this article.

Figures

Figure 1
Figure 1
Results of the principal components (PCs) analysis using serum adiponectin concentration (Adipo) and urinary albumin/creatinine ratio (uACR). Eigenvectors with the score plots and loading patterns of PCs are shown in the upper and lower panels, respectively. Adipo and uACR were log-transformed for the analysis to normalize their distributions.
Figure 2
Figure 2
ROC curves of serum adiponectin and serum adiponectin-to-uACR ratio to predict T2D. Red line: serum adiponectin concentration; green line: uACR ratio. The differences in the AUCs between the analyses are shown below the plot. ROC, receiver operating characteristic; T2D, type 2 diabetes; AUC, area under the ROC curve; uACR, urinary albumin/creatinine ratio.
See this image and copyright information in PMC

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References

    1. Achari A.E., Jain S.K. Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction. Int. J. Mol. Sci. 2017;18:1321. doi: 10.3390/ijms18061321. - DOI - PMC - PubMed
    1. Weyer C., Funahashi T., Tanaka S., Hotta K., Matsuzawa Y., Pratley R.E., Tataranni P.A. Hypoadiponectinemia in obesity and type 2 diabetes: Close association with insulin resistance and hyperinsulinemia. J. Clin. Endocrinol. Metab. 2001;86:1930–1935. doi: 10.1210/jcem.86.5.7463. - DOI - PubMed
    1. Berg A.H., Combs T.P., Scherer P.E. ACRP30/adiponectin: An adipokine regulating glucose and lipid metabolism. Trends Endocrinol. Metab. 2002;3:84–89. doi: 10.1016/S1043-2760(01)00524-0. - DOI - PubMed
    1. Choi H.M., Doss H.M., Kim K.S. Multifaceted Physiological Roles of Adiponectin in Inflammation and Diseases. Int. J. Mol. Sci. 2020;21:1219. doi: 10.3390/ijms21041219. - DOI - PMC - PubMed
    1. Yamauchi T., Kamon J., Waki H., Terauchi Y., Kubota N., Hara K., Mori Y., Ide T., Murakami K., Tsuboyama-Kasaoka N., et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med. 2001;7:941–946. doi: 10.1038/90984. - DOI - PubMed

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