Lactate: a pearl dropped in the ocean-an overlooked signal molecule in physiology and pathology
- PMID: 36511218
- DOI: 10.1002/cbin.11975
Lactate: a pearl dropped in the ocean-an overlooked signal molecule in physiology and pathology
Abstract
Lactate, once recognized as a wasty product from anaerobic glycolysis, is proved to be a pivotal signal molecule. Lactate accumulation occurs in diverse physiological and pathological settings due to the imbalance between lactate production and clearance. Under the condition with drastic changes in local microenvironment, such as tumorigenesis, inflammation, and microbial infection, the glycolysis turns to be active in surrounding cells leading to increased lactate release. Meanwhile, lactate can be utilized by these cells as an energy substrate and acts as a signal molecule to regulate cell functions through receptor-dependent or independent pathways. In this review, we tended to tease out the contribution of lactate in tumor progression and immunomodulation. And we also discussed the accessory role of lactate, beyond as the energy source only, in the growth of invading pathogens.
Keywords: cancer; immunomodulation; infection; lactate; signal molecule.
© 2022 International Federation for Cell Biology.
Similar articles
-
The Science and Translation of Lactate Shuttle Theory.Cell Metab. 2018 Apr 3;27(4):757-785. doi: 10.1016/j.cmet.2018.03.008. Cell Metab. 2018. PMID: 29617642 Review.
-
Lactate as a signaling molecule: Journey from dead end product of glycolysis to tumor survival.Front Biosci (Landmark Ed). 2019 Jan 1;24(2):366-381. doi: 10.2741/4723. Front Biosci (Landmark Ed). 2019. PMID: 30468661 Review.
-
The lactate sensor GPR81 regulates glycolysis and tumor growth of breast cancer.Sci Rep. 2022 Apr 15;12(1):6261. doi: 10.1038/s41598-022-10143-w. Sci Rep. 2022. PMID: 35428832 Free PMC article.
-
In vitro and in vivo Effects of Lactate on Metabolism and Cytokine Production of Human Primary PBMCs and Monocytes.Front Immunol. 2018 Nov 12;9:2564. doi: 10.3389/fimmu.2018.02564. eCollection 2018. Front Immunol. 2018. PMID: 30483253 Free PMC article.
-
[Liver metabolism during cold ischemic incubation in UW solution in the rat model].Langenbecks Arch Chir. 1997;382(6):343-8. doi: 10.1007/s004230050078. Langenbecks Arch Chir. 1997. PMID: 9498207 German.
Cited by
-
Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies.Aging (Albany NY). 2023 Feb 28;15(4):947-981. doi: 10.18632/aging.204565. Aging (Albany NY). 2023. PMID: 36849157 Free PMC article.
References
REFERENCES
-
- Adeva-Andany, M., López-Ojén, M., Funcasta-Calderón, R., Ameneiros-Rodríguez, E., Donapetry-García, C., Vila-Altesor, M., & Rodríguez-Seijas, J. (2014). Comprehensive review on lactate metabolism in human health. Mitochondrion, 17, 76-100.
-
- Ahmed, K., Tunaru, S., Tang, C., Müller, M., Gille, A., Sassmann, A., Hanson, J., & Offermanns, S. (2010). An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81. Cell Metabolism, 11(4), 311-319.
-
- Alberti, K. G. M., Cohen, R. D., & Woods, H. F. (1974). Lactic acidosis and hyperlactatemia. The Lancet, 2(7895), 1519-1520.
-
- Bakker, J., & de Lima, A. (2004). Increased blood lacate levels: An important warning signal in surgical practice. Critical Care, 8(2), 96-98.
-
- Bakker, J., Postelnicu, R., & Mukherjee, V. (2020). Lactate. Critical Care Clinics, 36(1), 115-124.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources