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Review
. 2022 Dec 3;12(12):1811.
doi: 10.3390/biom12121811.

Considerations for the Use of Photobiomodulation in the Treatment of Retinal Diseases

Chun-Xia Zhang  1 , Yan Lou  2 , Jing Chi  1 , Xiao-Li Bao  1 , Bin Fan  1 , Guang-Yu Li  1
Affiliations
Review

Considerations for the Use of Photobiomodulation in the Treatment of Retinal Diseases

Chun-Xia Zhang et al. Biomolecules. .

Abstract

Photobiomodulation (PBM) refers to the beneficial effect produced from low-energy light irradiation on target cells or tissues. Increasing evidence in the literature suggests that PBM plays a positive role in the treatment of retinal diseases. However, there is great variation in the light sources and illumination parameters used in different studies, resulting in significantly different conclusions regarding PBM's therapeutic effects. In addition, the mechanism by which PBM improves retinal function has not been fully elucidated. In this study, we conducted a narrative review of the published literature on PBM for treating retinal diseases and summarized the key illumination parameters used in PBM. Furthermore, we explored the potential molecular mechanisms of PBM at the retinal cellular level with the goal of providing evidence for the improved utilization of PBM in the treatment of retinal diseases.

Keywords: PBM; illumination parameters; light irradiation; red light; retinal diseases.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of the influence of light on intracellular redox levels. Photon energy facilitates the dissociation of nitric oxide (NO) from the binding site of cytochrome C oxidase and subsequently promotes oxygen binding to the dissociated site, to enhance mitochondrial respiration and ATP generation.
See this image and copyright information in PMC

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