Periodontal diseases assessed by average bone resorption are associated with microvascular complications in patients with type 2 diabetes

doi:10.1007/s13340-022-00591-0

. 2022 Jun 27;14(1):32-39.

doi: 10.1007/s13340-022-00591-0. eCollection 2023 Jan.

Periodontal diseases assessed by average bone resorption are associated with microvascular complications in patients with type 2 diabetes

Noriko Sugi¹, Eri Eguchi², Ayaka Tsuboi³, Kazu Hatanaka³, Shogo Takashiba³, Yuri Kira⁴, Masako Miura⁴, Keiki Ogino⁵, Keita Hirano⁶, Takahiko Nakagawa⁷, Kentaro Doi^{4

8}

Affiliations

¹ Kyoto Oral Health Center, Rakuwakai Otowa Hospital, 2 Otowachinjicho, Yamashina-ku, Kyoto, Japan.
² Department of Public Health, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University, Okayama, Japan.
³ Department of Pathophysiology-Periodontal Science, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University, Okayama, Japan.
⁴ Diabetes and Endocrinology Lifestyle-Related Disease Center, Rakuwakai Otowa Hospital, Kyoto, Japan.
⁵ Department of Environmental Medicine, Faculty of Medicine, Kochi University, Kochi, Japan.
⁶ Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
⁷ Department of Nephrology, Rakuwakai Otowa Hospital, Kyoto, Japan.
⁸ Takashima Municipal Hospital, Shiga, Japan.

PMID: 36636165
PMCID: PMC9829934
DOI: 10.1007/s13340-022-00591-0

Periodontal diseases assessed by average bone resorption are associated with microvascular complications in patients with type 2 diabetes

Noriko Sugi et al. Diabetol Int. 2022.

. 2022 Jun 27;14(1):32-39.

doi: 10.1007/s13340-022-00591-0. eCollection 2023 Jan.

Authors

Noriko Sugi¹, Eri Eguchi², Ayaka Tsuboi³, Kazu Hatanaka³, Shogo Takashiba³, Yuri Kira⁴, Masako Miura⁴, Keiki Ogino⁵, Keita Hirano⁶, Takahiko Nakagawa⁷, Kentaro Doi^{4

8}

Affiliations

¹ Kyoto Oral Health Center, Rakuwakai Otowa Hospital, 2 Otowachinjicho, Yamashina-ku, Kyoto, Japan.
² Department of Public Health, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University, Okayama, Japan.
³ Department of Pathophysiology-Periodontal Science, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University, Okayama, Japan.
⁴ Diabetes and Endocrinology Lifestyle-Related Disease Center, Rakuwakai Otowa Hospital, Kyoto, Japan.
⁵ Department of Environmental Medicine, Faculty of Medicine, Kochi University, Kochi, Japan.
⁶ Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
⁷ Department of Nephrology, Rakuwakai Otowa Hospital, Kyoto, Japan.
⁸ Takashima Municipal Hospital, Shiga, Japan.

PMID: 36636165
PMCID: PMC9829934
DOI: 10.1007/s13340-022-00591-0

Abstract

Periodontal disease often develops in patients with diabetes, and further exacerbated with diabetic complications. It would be clinically important to clarify the relationship between diabetic microvascular diseases and periodontal disease. This study aimed to evaluate the association between periodontal disease and diabetic complications in patients with type 2 diabetes with poor glycemic control. A total of 447 patients with type 2 diabetes hospitalized at Rakuwakai Otowa Hospital, Japan, were initially recruited in this study. After excluding 134 patients who lacked clinical data or were edentulous, 312 were included in our study. The severity of periodontal disease was evaluated based on the average bone resorption rate. Patients with diabetic nephropathy developed severe periodontal disease (multivariate-adjusted odds ratio, 3.00 [95% CI 1.41-5.19]). Diabetic neuropathy was positively associated with the severity of periodontal disease; the multivariate-adjusted odds ratio (95% CI) was 1.62 (0.87‒2.99) for moderate and 4.26 (2.21‒8.20) for severe periodontal disease. In contrast, diabetic retinopathy was linked with moderate periodontal disease (multivariate-adjusted odds ratio 2.23 [95% CI 1.10-4.10]), but not with severe conditions (multivariate-adjusted odds ratio 0.92 [95% CI 0.67-3.07]). In conclusion, periodontal disease, evaluated by average bone resorption rate, was associated with diabetic nephropathy and neuropathy.

Supplementary information: The online version contains supplementary material available at 10.1007/s13340-022-00591-0.

Keywords: Bone resorption rate; Diabetic complications; Diabetic nephropathy; Diabetic neuropathy; Diabetic retinopathy; Periodontal disease.

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Conflict of interest statement

Conflict of interestAll authors declare no conflict interest associated with this manuscript.

Figures

**Fig. 1**
Flow chart for study population

See this image and copyright information in PMC

References

1. Taylor GW, Burt BA, Becker MP, Genco RJ, Shlossman M, Knowler WC, et al. Severe periodontitis and risk for poor glycemic control in patients with non-insulin-dependent diabetes mellitus. J Periodontol. 1996;67:1085–1093. doi: 10.1902/jop.1996.67.10s.1085. - DOI - PubMed
1. Demmer RT, Jacobs DR, Jr, Desvarieux M. Periodontal disease and incident type 2 diabetes: results from the First National Health and Nutrition Examination Survey and its epidemiologic follow-up study. Diabetes Care. 2008;31:1373–1379. doi: 10.2337/dc08-0026. - DOI - PMC - PubMed
1. Costa FO, Miranda Cota LO, Pereira Lages EJ, Soares Dutra Oliveira AM, Dutra Oliveira PA, Cyrino RM, et al. Progression of periodontitis and tooth loss associated with glycemic control in individuals undergoing periodontal maintenance therapy: a 5-year follow-up study. J Periodontol. 2013;84:595–605. doi: 10.1902/jop.2012.120255. - DOI - PubMed
1. Nelson RG, Shlossman M, Budding LM, Pettitt DJ, Saad MF, Genco RJ, et al. Periodontal disease and NIDDM in Pima Indians. Diabetes Care. 1990;13:836–840. doi: 10.2337/diacare.13.8.836. - DOI - PubMed
1. Tsai C, Hayes C, Taylor GW. Glycemic control of type 2 diabetes and severe periodontal disease in the US adult population. Community Dent Oral Epidemiol. 2002;30:182–192. doi: 10.1034/j.1600-0528.2002.300304.x. - DOI - PubMed

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[1] Taylor GW, Burt BA, Becker MP, Genco RJ, Shlossman M, Knowler WC, et al. Severe periodontitis and risk for poor glycemic control in patients with non-insulin-dependent diabetes mellitus. J Periodontol. 1996;67:1085–1093. doi: 10.1902/jop.1996.67.10s.1085. - DOI - PubMed

[2] Taylor GW, Burt BA, Becker MP, Genco RJ, Shlossman M, Knowler WC, et al. Severe periodontitis and risk for poor glycemic control in patients with non-insulin-dependent diabetes mellitus. J Periodontol. 1996;67:1085–1093. doi: 10.1902/jop.1996.67.10s.1085. - DOI - PubMed

[3] Demmer RT, Jacobs DR, Jr, Desvarieux M. Periodontal disease and incident type 2 diabetes: results from the First National Health and Nutrition Examination Survey and its epidemiologic follow-up study. Diabetes Care. 2008;31:1373–1379. doi: 10.2337/dc08-0026. - DOI - PMC - PubMed

[4] Demmer RT, Jacobs DR, Jr, Desvarieux M. Periodontal disease and incident type 2 diabetes: results from the First National Health and Nutrition Examination Survey and its epidemiologic follow-up study. Diabetes Care. 2008;31:1373–1379. doi: 10.2337/dc08-0026. - DOI - PMC - PubMed

[5] Costa FO, Miranda Cota LO, Pereira Lages EJ, Soares Dutra Oliveira AM, Dutra Oliveira PA, Cyrino RM, et al. Progression of periodontitis and tooth loss associated with glycemic control in individuals undergoing periodontal maintenance therapy: a 5-year follow-up study. J Periodontol. 2013;84:595–605. doi: 10.1902/jop.2012.120255. - DOI - PubMed

[6] Costa FO, Miranda Cota LO, Pereira Lages EJ, Soares Dutra Oliveira AM, Dutra Oliveira PA, Cyrino RM, et al. Progression of periodontitis and tooth loss associated with glycemic control in individuals undergoing periodontal maintenance therapy: a 5-year follow-up study. J Periodontol. 2013;84:595–605. doi: 10.1902/jop.2012.120255. - DOI - PubMed

[7] Nelson RG, Shlossman M, Budding LM, Pettitt DJ, Saad MF, Genco RJ, et al. Periodontal disease and NIDDM in Pima Indians. Diabetes Care. 1990;13:836–840. doi: 10.2337/diacare.13.8.836. - DOI - PubMed

[8] Nelson RG, Shlossman M, Budding LM, Pettitt DJ, Saad MF, Genco RJ, et al. Periodontal disease and NIDDM in Pima Indians. Diabetes Care. 1990;13:836–840. doi: 10.2337/diacare.13.8.836. - DOI - PubMed

[9] Tsai C, Hayes C, Taylor GW. Glycemic control of type 2 diabetes and severe periodontal disease in the US adult population. Community Dent Oral Epidemiol. 2002;30:182–192. doi: 10.1034/j.1600-0528.2002.300304.x. - DOI - PubMed

[10] Tsai C, Hayes C, Taylor GW. Glycemic control of type 2 diabetes and severe periodontal disease in the US adult population. Community Dent Oral Epidemiol. 2002;30:182–192. doi: 10.1034/j.1600-0528.2002.300304.x. - DOI - PubMed

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Periodontal diseases assessed by average bone resorption are associated with microvascular complications in patients with type 2 diabetes

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Periodontal diseases assessed by average bone resorption are associated with microvascular complications in patients with type 2 diabetes

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Abstract

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