Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Feb;9(2):e13238.
doi: 10.1016/j.heliyon.2023.e13238. Epub 2023 Jan 26.

Hypoxia modeling techniques: A review

Nataliya Salyha  1 , Iryna Oliynyk  1
Affiliations
Review

Hypoxia modeling techniques: A review

Nataliya Salyha et al. Heliyon. 2023 Feb.

Abstract

Hypoxia is the main cause and effect of a large number of diseases, including the most recent one facing the world, the coronavirus disease (COVID-19). Hypoxia is divided into short-term, long-term, and periodic, it can be the result of diseases, climate change, or living and traveling in the high mountain regions of the world. Since each type of hypoxia can be a cause and a consequence of various physiological changes, the methods for modeling these hypoxias are also different. There are many techniques for modeling hypoxia under experimental conditions. The most common animal for modeling hypoxia is a rat. Hypoxia models (hypoxia simulations) in rats are a tool to study the effect of various conditions on the oxygen supply of the body. These models can provide a necessary information to understand hypoxia and also provide effective treatment, highlighting the importance of various reactions of the body to hypoxia. The main parameters when choosing a model should be reproducibility and the goal that the scientist wants to achieve. Hypoxia in rats can be reproduced both ways exogenously and endogenously. The reason for writing this review was the aim to systematize the models of rats available in the literature in order to facilitate their selection by scientists. The relative strengths and limitations of each model need to be identified and understood in order to evaluate the information obtained from these models and extrapolate these results to humans to develop the necessary generalizations. Despite these problems, animal models have been and remain vital to understanding the mechanisms involved in the development and progression of hypoxia. The eligibility criteria for the selected studies was a comprehensive review of the methods and results obtained from the studies. This made it possible to make generalizations and give recommendations on the application of these methods. The review will assist scientists in choosing an appropriate hypoxia simulation method, as well as assist in interpreting the results obtained with these methods.

Keywords: Hypoxia; Methods; Modeling; Rats; Simulation.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Number of publications related to hypoxia in PubMed.
Fig. 2
Fig. 2
Search queries for hypoxia and hypoxemia.
Fig. 3
Fig. 3
Сlassification of hypoxia modeling methods.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Nath B., Szabo G. Hypoxia and hypoxia inducible factors:diverse roles in liver diseases. Hepatology. 2012;55(2):622–633. - PMC - PubMed
    1. Biddlestone J., Bandarra D., Rocha S. The role of hypoxia in inflammatory disease. Int. J. Mol. Med. 2015;35:859–869. - PMC - PubMed
    1. Callea L., Bonati L., Motta S. Metadynamics-based approaches for modeling the hypoxia-inducible factor 2α ligand binding process. J. Chem. Theor. Comput. 2021;17(7):3841–3851. - PMC - PubMed
    1. Guan W.J., Ni Z.Y., Hu Y., Liang W.H., Ou C.Q., He J.X., et al. Clinical characteristics of coronavirus disease 2019 in China. N. Engl. J. Med. 2020;382:1708–1720. - PMC - PubMed
    1. Jiang S.B., Xia S., Ying T.L., Lu L. A novel coronavirus (2019-nCoV) causing pneumonia-associated respiratory syndrome. Cell. Mol. Immunol. 2020;17:554. - PMC - PubMed

LinkOut - more resources

-