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. 2022 Dec;74(Suppl 3):5037-5043.
doi: 10.1007/s12070-021-02676-9. Epub 2021 Jun 11.

Trace Elements Levels in Serum of Patients with Recurrent Respiratory Papillomatosis

Aswin Chandran  1 , Hitesh Verma  1 , Javed Ahsan Quadri  2
Affiliations

Trace Elements Levels in Serum of Patients with Recurrent Respiratory Papillomatosis

Aswin Chandran et al. Indian J Otolaryngol Head Neck Surg. 2022 Dec.

Abstract

Recurrent respiratory papillomatosis (RRP) is a chronic airway disease characterized by unpredictable recurrences and relapses. Our study aimed to identify the role of trace elements, a proven risk factor for various malignancies, in the development of papilloma and to correlate their serum levels with various disease parameters. 32 RRP patients with 20 age-matched controls were recruited in the study. Analysis of serum trace elements was performed by atomic absorption spectrophotometry in whole blood samples from cases and controls. The serum levels of trace elements were correlated with age of onset, history of previous surgeries, tracheostomy status, Derkay's score, and presence of dysplasia. Among the 32 cases there were 18 males and 14 females with a mean age of 20.85 years (range: 3-60 years). The mean serum levels of Thallium, Zinc, and Gallium were higher among cases compared to their controls whereas the levels of Arsenic, Copper, Cobalt, Selenium, Cadmium, and Lead were higher in control subjects compared to RRP patients. There was a statistically significant correlation of serum level of Cobalt with more than 3 surgeries per year (p = 0.02), Gallium and Thallium with Derkay's score of more than 20 (p = 0.04 and 0.05) and Lead, Arsenic and Gallium with presence tissue dysplasia (p = 0.05, 0.04 and 0.04). Our study had shown a variable association of trace elements in RRP patients. The usefulness of these values need to be completely elucidated and our study calls for future investigations to identify the casual association of various trace elements in the pathogenesis of RRP.

Keywords: Heavy metals; RRP; Respiratory papilloma; Trace elements.

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Conflict of interest statement

Conflict of interestThe authors declare that they have no financial or non-financial conflicts of interest.

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