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Review
. 2023 Feb 15;13(1):6.
doi: 10.1007/s13659-023-00369-0.

Traditional Chinese medicine Euodiae Fructus: botany, traditional use, phytochemistry, pharmacology, toxicity and quality control

Si-Jia Xiao #  1 , Xi-Ke Xu #  1 , Wei Chen #  1 , Jia-Yun Xin  2 , Wen-Lin Yuan  1 , Xian-Peng Zu  3 , Yun-Heng Shen  4
Affiliations
Review

Traditional Chinese medicine Euodiae Fructus: botany, traditional use, phytochemistry, pharmacology, toxicity and quality control

Si-Jia Xiao et al. Nat Prod Bioprospect. .

Abstract

Euodiae Fructus, referred to as "Wuzhuyu" in Chinese, has been used as local and traditional herbal medicines in many regions, especially in China, Japan and Korea, for the treatment of gastrointestinal disorders, headache, emesis, aphtha, dermatophytosis, dysentery, etc. Substantial investigations into their chemical and pharmacological properties have been performed. Recently, interest in this plant has been focused on the different structural types of alkaloids like evodiamine, rutaecarpine, dehydroevodiamine and 1-methyl-2-undecyl-4(1H)-quinolone, which exhibit a wide range of pharmacological activities in preclinical models, such as anticancer, antibacterial, anti-inflammatory, anti-cardiovascular disease, etc. This review summarizes the up-to-date and comprehensive information concerning the botany, traditional uses, phytochemistry, pharmacology of Euodiae Fructus together with the toxicology and quality control, and discusses the possible direction and scope for future research on this plant.

Keywords: Euodiae Fructus; Pharmacology; Phytochemistry; Toxicology; Traditional uses.

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Conflict of interest statement

The authors declare that no conflict of interest.

Figures

Fig. 1
Fig. 1
Multiple pharmacological effects of Euodiae Fructus
Fig. 2
Fig. 2
Indole alkaloids isolated from Euodiae Fructus
Fig. 3
Fig. 3
Quinoline alkaloids isolated from Euodiae Fructus
Fig. 4
Fig. 4
Other alkaloids isolated from Euodiae Fructus
Fig. 5
Fig. 5
Limonoids isolated from Euodiae Fructus
Fig. 6
Fig. 6
Other terpenoids isolated from Euodiae Fructus
Fig.7
Fig.7
Steroids isolated from Euodiae Fructus
Fig. 8
Fig. 8
Flavonoids isolated from Euodiae Fructus
Fig.9
Fig.9
Other phenols isolated from Euodiae Fructus
Fig.10
Fig.10
Other compounds isolated from Euodiae Fructus
See this image and copyright information in PMC

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