Harnessing Nanomaterials for Cancer Sonodynamic Immunotherapy
- PMID: 36881527
- DOI: 10.1002/adma.202211130
Harnessing Nanomaterials for Cancer Sonodynamic Immunotherapy
Abstract
Immunotherapy has made remarkable strides in cancer therapy over the past decade. However, such emerging therapy still suffers from the low response rates and immune-related adverse events. Various strategies have been developed to overcome these serious challenges. Therein, sonodynamic therapy (SDT), as a non-invasive treatment, has received ever-increasing attention especially in the treatment of deep-seated tumors. Significantly, SDT can effectively induce immunogenic cell death to trigger systemic anti-tumor immune response, termed sonodynamic immunotherapy. The rapid development of nanotechnology has revolutionized SDT effects with robust immune response induction. As a result, more and more innovative nanosonosensitizers and synergistic treatment modalities are established with superior efficacy and safe profile. In this review, the recent advances in cancer sonodynamic immunotherapy are summarized with a particular emphasis on how nanotechnology can be explored to harness SDT for amplifying anti-tumor immune response. Moreover, the current challenges in this field and the prospects for its clinical translation are also presented. It is anticipated that this review can provide rational guidance and facilitate the development of nanomaterials-assisted sonodynamic immunotherapy, helping to pave the way for next-generation cancer therapy and eventually achieve a durable response in patients.
Keywords: immunosuppressive tumor microenvironment; immunotherapy; nanomaterials; nanosonosensitizers; sonodynamic therapy.
© 2023 Wiley-VCH GmbH.
Similar articles
-
Peptide-Appended Nanosonosensitizers Targeting Tumor Glycolysis for Synergistic Sonodynamic-Immunometabolic Therapy of Spinal-Metastasized Tumors.Adv Mater. 2023 Oct;35(42):e2304246. doi: 10.1002/adma.202304246. Epub 2023 Sep 15. Adv Mater. 2023. PMID: 37460111
-
Nanosonosensitizer-Augmented Sonodynamic Therapy Combined with Checkpoint Blockade for Cancer Immunotherapy.Int J Nanomedicine. 2021 Mar 5;16:1889-1899. doi: 10.2147/IJN.S290796. eCollection 2021. Int J Nanomedicine. 2021. PMID: 33707944 Free PMC article.
-
Organic Sonodynamic Materials for Combination Cancer Immunotherapy.Adv Mater. 2023 Dec;35(51):e2303059. doi: 10.1002/adma.202303059. Epub 2023 Oct 31. Adv Mater. 2023. PMID: 37263297 Review.
-
Emerging Sonodynamic Therapy-Based Nanomedicines for Cancer Immunotherapy.Adv Sci (Weinh). 2023 Jan;10(2):e2204365. doi: 10.1002/advs.202204365. Epub 2022 Nov 27. Adv Sci (Weinh). 2023. PMID: 36437106 Free PMC article. Review.
-
Nanosonosensitizers With Ultrasound-Induced Reactive Oxygen Species Generation for Cancer Sonodynamic Immunotherapy.Front Bioeng Biotechnol. 2021 Sep 30;9:761218. doi: 10.3389/fbioe.2021.761218. eCollection 2021. Front Bioeng Biotechnol. 2021. PMID: 34660560 Free PMC article. Review.
Cited by
-
Metal-Organic Framework Nanomaterials as a Medicine for Catalytic Tumor Therapy: Recent Advances.Nanomaterials (Basel). 2024 May 3;14(9):797. doi: 10.3390/nano14090797. Nanomaterials (Basel). 2024. PMID: 38727391 Free PMC article. Review.
-
Exploiting Sound for Emerging Applications of Extracellular Vesicles.Nano Res. 2024 Feb;17(2):462-475. doi: 10.1007/s12274-023-5840-6. Epub 2023 Jul 1. Nano Res. 2024. PMID: 38712329 Free PMC article.
-
Nanobiotechnology augmented cancer stem cell guided management of cancer: liquid-biopsy, imaging, and treatment.J Nanobiotechnology. 2024 Apr 12;22(1):176. doi: 10.1186/s12951-024-02432-5. J Nanobiotechnology. 2024. PMID: 38609981 Free PMC article. Review.
-
Cancer diagnosis and treatment platform based on manganese-based nanomaterials.Front Bioeng Biotechnol. 2024 Mar 1;12:1363569. doi: 10.3389/fbioe.2024.1363569. eCollection 2024. Front Bioeng Biotechnol. 2024. PMID: 38497051 Free PMC article. Review.
-
Nanomaterials augmented bioeffects of ultrasound in cancer immunotherapy.Mater Today Bio. 2023 Dec 22;24:100926. doi: 10.1016/j.mtbio.2023.100926. eCollection 2024 Feb. Mater Today Bio. 2023. PMID: 38179429 Free PMC article. Review.
References
-
- J. M. Banales, J. J. G. Marin, A. Lamarca, P. M. Rodrigues, S. A. Khan, L. R. Roberts, V. Cardinale, G. Carpino, J. B. Andersen, C. Braconi, D. F. Calvisi, M. J. Perugorria, L. Fabris, L. Boulter, R. I. R. Macias, E. Gaudio, D. Alvaro, S. A. Gradilone, M. Strazzabosco, M. Marzioni, C. Coulouarn, L. Fouassier, C. Raggi, P. Invernizzi, J. C. Mertens, A. Moncsek, S. Rizvi, J. Heimbach, B. G. Koerkamp, J. Bruix, et al., Nat. Rev. Gastroenterol. Hepatol. 2020, 17, 557.
-
- a) E. Frei, 3rd, Cancer 1982, 50, 1979;
-
- b) Y. Lee, S. L. Auh, Y. Wang, B. Burnette, Y. Wang, Y. Meng, M. Beckett, R. Sharma, R. Chin, T. Tu, R. R. Weichselbaum, Y. Fu, Blood 2009, 114, 589;
-
- c) G. Rosen, R. C. Marcove, B. Caparros, A. Nirenberg, C. Kosloff, A. G. Huvos, Cancer 1979, 43, 2163.
-
- A. Urruticoechea, R. Alemany, J. Balart, A. Villanueva, F. Vinals, G. Capella, Curr. Pharm. Des. 2010, 16, 3.
Publication types
MeSH terms
Substances
Grants and funding
- 52202356/National Natural Science Foundation of China
- 82222035/National Natural Science Foundation of China
- 2021-RC350-001/Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences
- 2021-I2M-1-026/CAMS Innovation Fund for Medical Sciences
- 3332022044/Fundamental Research Funds for the Central Universities
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous