Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases
- PMID: 36997729
- PMCID: PMC10062691
- DOI: 10.1007/s10787-023-01136-w
Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases
Abstract
Chemokines belong to the family of cytokines with chemoattractant properties that regulate chemotaxis and leukocyte migration, as well as the induction of angiogenesis and maintenance of hemostasis. Curcumin, the major component of the Curcuma longa rhizome, has various pharmacological actions, including anti-inflammatory, immune-regulatory, anti-oxidative, and lipid-modifying properties. Chemokines and chemokine receptors are influenced/modulated by curcumin. Thus, the current review focuses on the molecular mechanisms associated with curcumin's effects on chemoattractant cytokines, as well as putting into context the many studies that have reported curcumin-mediated regulatory effects on inflammatory conditions in the organs/systems of the body (e.g., the central nervous system, liver, and cardiovascular system). Curcumin's effects on viral and bacterial infections, cancer, and adverse pregnancy outcomes are also reviewed.
Keywords: Cancer; Chemokine; Curcumin; Cytokine; Infection; Inflammation.
© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
Conflict of interest statement
Muhammed Majeed is the founder of Sami-Sabinsa group of companies.
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References
-
- Aggarwal BB, Shishodia S, Takada Y, Banerjee S, Newman RA, Bueso-Ramos CE, et al. Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. Clin Cancer Res. 2005;11(20):7490–7498. doi: 10.1158/1078-0432.ccr-05-1192. - DOI - PubMed
-
- Alidadi M, Jamialahmadi T, Cicero AFG, Bianconi V, Pirro M, Banach M, et al. The potential role of plant-derived natural products in improving arterial stiffness: a review of dietary intervention studies (Review) Trends Food Sci Technol. 2020;99:426–440. doi: 10.1016/j.tifs.2020.03.026. - DOI
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