Efficacy and safety of Weifuchun tablet for chronic atrophic gastritis: A systematic review and meta-analysis
- PMID: 37053262
- PMCID: PMC10101393
- DOI: 10.1371/journal.pone.0284411
Efficacy and safety of Weifuchun tablet for chronic atrophic gastritis: A systematic review and meta-analysis
Abstract
Background: Chronic atrophic gastritis is a significant premalignant lesion of gastric carcinoma. There is a great need to prevent the progression to gastric carcinoma through early intervention and treatment for chronic atrophic gastritis. Weifuchun, a famous Chinese patent drug, has been widely used for chronic atrophic gastritis in China. However, it remains unclear whether Weifuchun is effective for atrophic gastritis.
Objective: To determine the effectiveness and safety of Weifuchun for chronic atrophic gastritis.
Methods: We systematically retrieved seven databases (Cochrane Library, EMBASE, PubMed, China National Knowledge Infrastructure, Wanfang database, Chinese Scientific Journals Database, and Chinese Biological Medical Database) from their inception to October 5, 2022. Methodological quality was examined using the Cochrane Risk of bias tool. We also used RevMan 5.4 software for statistical analysis to examine the effectiveness and safety of Weifuchun.
Results: Fifteen studies with 1,488 patients were enrolled in this meta-analysis. The study indicated that Weifuchun was more effective (RR 1.52; 95% CI 1.41, 1.63; p<0.00001) than Western medicine and other Chinese patent medicine. In addition, Weifuchun was more effective in improving gastric mucosal under gastroscopy, improving histopathologic changes of gastric mucosal, and inhibiting Helicobacter pylori. However, no significant difference in safety was examined between Weifuchun and the control group (RR 2.83; 95% CI 0.85, 9.38; P = 0.09).
Conclusions: The meta-analysis revealed a significant statistical difference with Weifuchun in effectiveness compared to the control group. However, there was no significant difference in safety. Thus, more high-quality clinical studies are needed in the future.
Trial registration: Registration number CRD42022365703.
Copyright: © 2023 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Conflict of interest statement
The authors have declared that no competing interests exist.
Figures
![Fig 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/10101393/bin/pone.0284411.g001.gif)
![Fig 2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/10101393/bin/pone.0284411.g002.gif)
![Fig 3](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/10101393/bin/pone.0284411.g003.gif)
![Fig 4](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/10101393/bin/pone.0284411.g004.gif)
![Fig 5](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/10101393/bin/pone.0284411.g005.gif)
![Fig 6](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/10101393/bin/pone.0284411.g006.gif)
![Fig 7](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/10101393/bin/pone.0284411.g007.gif)
![Fig 8](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/10101393/bin/pone.0284411.g008.gif)
![Fig 9](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/10101393/bin/pone.0284411.g009.gif)
![Fig 10](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/10101393/bin/pone.0284411.g010.gif)
Similar articles
-
Clinical efficacy of Weisu granule combined with Weifuchun tablet in the treatment of chronic atrophic gastritis and its effect on serum G-17, PG I and PG II levels.Am J Transl Res. 2022 Jan 15;14(1):275-284. eCollection 2022. Am J Transl Res. 2022. PMID: 35173844 Free PMC article.
-
Efficacy of Banxia Xiexin decoction for chronic atrophic gastritis: A systematic review and meta-analysis.PLoS One. 2020 Oct 27;15(10):e0241202. doi: 10.1371/journal.pone.0241202. eCollection 2020. PLoS One. 2020. PMID: 33108375 Free PMC article.
-
Effects of weifuchun tablet for chronic atrophic gastritis: A protocol for systematic review and meta-analysis.Medicine (Baltimore). 2020 May 29;99(22):e20374. doi: 10.1097/MD.0000000000020374. Medicine (Baltimore). 2020. PMID: 32481421
-
Systematic review with meta-analysis: diagnostic performance of the combination of pepsinogen, gastrin-17 and anti-Helicobacter pylori antibodies serum assays for the diagnosis of atrophic gastritis.Aliment Pharmacol Ther. 2017 Oct;46(7):657-667. doi: 10.1111/apt.14248. Epub 2017 Aug 7. Aliment Pharmacol Ther. 2017. PMID: 28782119 Review.
-
CHINESE HERBAL DECOCTION AS A COMPLEMENTARY THERAPY FOR ATROPHIC GASTRITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS.Afr J Tradit Complement Altern Med. 2017 Jun 5;14(4):297-319. doi: 10.21010/ajtcam.v14i4.33. eCollection 2017. Afr J Tradit Complement Altern Med. 2017. PMID: 28638893 Free PMC article. Review.
Cited by
-
Medicine for chronic atrophic gastritis: a systematic review, meta- and network pharmacology analysis.Ann Med. 2023;55(2):2299352. doi: 10.1080/07853890.2023.2299352. Epub 2024 Jan 3. Ann Med. 2023. PMID: 38170849 Free PMC article.
-
Rutaecarpine Ameliorates Murine N-Methyl-N'-Nitro-N-Nitrosoguanidine-Induced Chronic Atrophic Gastritis by Sonic Hedgehog Pathway.Molecules. 2023 Aug 28;28(17):6294. doi: 10.3390/molecules28176294. Molecules. 2023. PMID: 37687125 Free PMC article.
References
-
- Kakeji Y, Ishikawa T, Suzuki S, Akazawa K, Irino T, Miyashiro I, et al.. A retrospective 5-year survival analysis of surgically resected gastric cancer cases from the Japanese Gastric Cancer Association nationwide registry (2001–2013). Gastric Cancer. 2022;25(6):1082–1093. doi: 10.1007/s10120-022-01317-6 . - DOI - PubMed
-
- Correa P. Human gastric carcinogenesis: a multistep and multifactorial process—First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res. 1992;52(24):6735–40. . - PubMed
Publication types
MeSH terms
Substances
Associated data
Grants and funding
LinkOut - more resources
Full Text Sources