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Review
. 2023 Jun:162:114711.
doi: 10.1016/j.biopha.2023.114711. Epub 2023 Apr 20.

Cellular senescence - Molecular mechanisms of intervertebral disc degeneration from an immune perspective

Chao Song  1 , Yan Zhou  2 , Kang Cheng  1 , Fei Liu  1 , Weiye Cai  1 , Daqian Zhou  1 , Rui Chen  1 , Houyin Shi  3 , Zhijiang Fu  4 , Jingwen Chen  5 , Zongchao Liu  6
Affiliations
Free article
Review

Cellular senescence - Molecular mechanisms of intervertebral disc degeneration from an immune perspective

Chao Song et al. Biomed Pharmacother. 2023 Jun.
Free article

Abstract

Intervertebral disc degeneration (IVDD) is a frequent and intractable chronic condition in orthopedics that causes enormous discomfort in patients' lives and thoughts, as well as a significant economic burden on society and the nation. As a result, understanding the pathophysiology of IVDD is critical. The pathophysiology of IVDD has been linked to numerous variables, including oxidative stress, apoptosis, matrix metalloproteinases, and inflammatory factors. Cellular senescence has recently attracted a lot of attention in the study of age-related diseases. It has been discovered that IVDD is intimately linked to human senescence, in which nucleus pulposus cell senescence may play a significant role. Previously, our group did a comprehensive and systematic clarification of the pathogenesis of IVDD from an immune perspective and discovered that the fundamental pathogenesis of IVDD is inflammatory upregulation and nucleus pulposus cell death caused by an imbalance in the immune microenvironment. In this review, we will treat nucleus pulposus cell senescence as a novelty point to clarify the pathophysiology of IVDD and further explore the probable relationship between senescence and immunity along with the dysregulation of the immunological microenvironment to propose new therapeutic approaches for IVDD.

Keywords: Immunomodulation; Intervertebral disc degeneration; Nucleus pulposus cells; Senescence.

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Conflict of interest statement

Conflict of Interest Statement The authors have no financial or proprietary interests in any material discussed in this article.

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