Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Mar 28;12(4):827.
doi: 10.3390/antiox12040827.

The Association of Physical Activity and Sedentary Behavior with Maternal and Cord Blood Anti-Oxidative Capacity and HDL Functionality: Findings of DALI Study

Saghi Zafaranieh  1 , Julia T Stadler  2 , Anja Pammer  2 , Gunther Marsche  2 , Mireille N M van Poppel  1 , Gernot Desoye  3 , Dali Core Investigator Group
Affiliations

The Association of Physical Activity and Sedentary Behavior with Maternal and Cord Blood Anti-Oxidative Capacity and HDL Functionality: Findings of DALI Study

Saghi Zafaranieh et al. Antioxidants (Basel). .

Abstract

Obesity is one of the most common health issues in pregnancy with short and long-term consequences for both mother and her offspring. Promoting moderate to vigorous physical activity (MVPA) and decreasing sedentary time (ST) could have a positive impact on weight and obesity management, and therefore adiposity-induced oxidative stress, inflammation, and atherogenesis. However, the effects of MVPA and ST on anti-oxidative and anti-atherogenic markers in pregnancy have not been studied to date. This study aimed to assess the association of longitudinally and objectively measured MVPA and ST in 122 overweight/obese women (BMI ≥ 29 kg/m2) with maternal and cord blood markers of oxidative stress measured by advanced oxidation protein products (AOPP), anti-oxidative capacity, as well as high-density lipoproteins (HDL) related paraoxonase-1 (PON-1) activity and cholesterol efflux. Linear regression models showed no associations of MVPA and ST with outcomes in maternal blood. In contrast, MVPA at <20 weeks and 24-28 weeks of gestation were positively associated with anti-oxidative capacity, as well as PON-1 activity of HDL in cord blood. MVPA at 35-37 weeks correlated with higher AOPP, as well as higher anti-oxidative capacity. ST <20 weeks was also positively associated with inhibition of oxidation in cord blood. We speculate that increasing MVPA of overweight/obese women during pregnancy attenuates the oxidative stress state in the new-born.

Keywords: antioxidative capacity; cholesterol efflux; obesity; physical activity; pregnancy; sedentary behavior.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Advanced oxidation protein products (AOPPs) (A), % inhibition of oxidation (B), AE activity (C), and cholesterol efflux (D), at three time points during pregnancy in maternal blood, and at term in cord blood. a Axis values logarithmically scaled. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
Figure 2
Figure 2
Regression coefficient estimates with 95% confidence intervals of the association between moderate-to-vigorous physical activity (MVPA= black) and % sedentary time (%ST = green) and maternal serum levels of (A) advanced oxidation protein products (AOPP), (B) serum anti-oxidative capacity (% inhibition of oxidation), (C) AE activity of PON-1, and (D) HDL cholesterol efflux capacity. a Log transformed values were used in the regression analyses.
Figure 3
Figure 3
Regression coefficient estimates with 95% confidence intervals of the association between moderate-to-vigorous physical activity (MVPA= black) and % sedentary time (%ST = green) and cord blood levels of advanced oxidation protein products (AOPP) (A), anti-oxidative capacity (% inhibition of oxidation) (B), AE activity of PON-1 (C), and HDL cholesterol efflux capacity (D). a Log transformed values were used in the regression analyses.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. World Health Organization: Obesity and overweight. [(accessed on 30 January 2023)]; Available online: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight.
    1. Corrales P., Vidal-Puig A., Medina-Gómez G. Obesity and pregnancy, the perfect metabolic storm. Eur. J. Clin. Nutr. 2021;75:1723–1734. doi: 10.1038/s41430-021-00914-5. - DOI - PubMed
    1. Ruiz-Ojeda F.J., Olza J., Gil Á., Aguilera C.M. Obesity. Academic Press; Cambridge, MA, USA: 2018. Oxidative Stress and Inflammation in Obesity and Metabolic Syndrome. Obesity: Oxidative Stress and Dietary Antioxidants; pp. 1–15. - DOI
    1. Burton G.J., Jauniaux E. Oxidative stress. Best Pract. Res. Clin. Obstet. Gynaecol. 2011;25:287–299. doi: 10.1016/j.bpobgyn.2010.10.016. - DOI - PMC - PubMed
    1. Ouimet M., Barrett T.J., Fisher E.A. HDL and Reverse Cholesterol Transport. Circ. Res. 2019;124:1505–1518. doi: 10.1161/CIRCRESAHA.119.312617. - DOI - PMC - PubMed

LinkOut - more resources

-