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Review
. 2023:103:341-435.
doi: 10.1007/978-3-031-26576-1_15.

Ageing, Metabolic Dysfunction, and the Therapeutic Role of Antioxidants

Ana L Santos  1 , Sanchari Sinha  2
Affiliations
Review

Ageing, Metabolic Dysfunction, and the Therapeutic Role of Antioxidants

Ana L Santos et al. Subcell Biochem. 2023.

Abstract

The gradual ageing of the world population has been accompanied by a dramatic increase in the prevalence of obesity and metabolic diseases, especially type 2 diabetes. The adipose tissue dysfunction associated with ageing and obesity shares many common physiological features, including increased oxidative stress and inflammation. Understanding the mechanisms responsible for adipose tissue dysfunction in obesity may help elucidate the processes that contribute to the metabolic disturbances that occur with ageing. This, in turn, may help identify therapeutic targets for the treatment of obesity and age-related metabolic disorders. Because oxidative stress plays a critical role in these pathological processes, antioxidant dietary interventions could be of therapeutic value for the prevention and/or treatment of age-related diseases and obesity and their complications. In this chapter, we review the molecular and cellular mechanisms by which obesity predisposes individuals to accelerated ageing. Additionally, we critically review the potential of antioxidant dietary interventions to counteract obesity and ageing.

Keywords: Ageing; Dietary interventions; Inflammation; Metabolic syndrome; Nutraceuticals; Obesity; Oxidative stress.

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References

    1. Aagaard-Tillery KM, Grove K, Bishop J et al (2008) Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome. J Mol Endocrinol 41:91–102. https://doi.org/10.1677/JME-08-0025 - DOI
    1. Abbas S, Wink M (2010) Epigallocatechin gallate inhibits beta amyloid oligomerization in Caenorhabditis elegans and affects the daf-2/insulin-like signaling pathway. Phytomedicine 17:902–909. https://doi.org/10.1016/j.phymed.2010.03.008 - DOI
    1. Abbatecola AM, Russo M, Barbieri M (2018) Dietary patterns and cognition in older persons. Curr Opin Clin Nutr Metab Care 21:10–13. https://doi.org/10.1097/MCO.0000000000000434 - DOI
    1. Aboonabi A, Aboonabi A (2020) Anthocyanins reduce inflammation and improve glucose and lipid metabolism associated with inhibiting nuclear factor-kappaB activation and increasing PPAR-γ gene expression in metabolic syndrome subjects. Free Radic Biol Med 150:30–39. https://doi.org/10.1016/j.freeradbiomed.2020.02.004 - DOI
    1. Abrahams S, Haylett WL, Johnson G et al (2019) Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress: a review. Neuroscience 406:1–21. https://doi.org/10.1016/j.neuroscience.2019.02.020 - DOI

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