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. 2022 Oct 28;37(4):230-254.
doi: 10.7555/JBR.36.20220125.

The effect of an adaptation to hypoxia on cardiac tolerance to ischemia/reperfusion

Natalia V Naryzhnaya  1 , Leonid N Maslov  1 , Ivan A Derkachev  1 , Huijie Ma  2 , Yi Zhang  2 , N Rajendra Prasad  3 , Nirmal Singh  4 , Feng Fu  5 , Jianming Pei  5 , Akpay Sarybaev  6   7 , Akylbek Sydykov  8   6
Affiliations

The effect of an adaptation to hypoxia on cardiac tolerance to ischemia/reperfusion

Natalia V Naryzhnaya et al. J Biomed Res. .

Abstract

The acute myocardial infarction (AMI) and sudden cardiac death (SCD), both associated with acute cardiac ischemia, are one of the leading causes of adult death in economically developed countries. The development of new approaches for the treatment and prevention of AMI and SCD remains the highest priority for medicine. A study on the cardiovascular effects of chronic hypoxia (CH) may contribute to the development of these methods. Chronic hypoxia exerts both positive and adverse effects. The positive effects are the infarct-reducing, vasoprotective, and antiarrhythmic effects, which can lead to the improvement of cardiac contractility in reperfusion. The adverse effects are pulmonary hypertension and right ventricular hypertrophy. This review presents a comprehensive overview of how CH enhances cardiac tolerance to ischemia/reperfusion. It is an in-depth analysis of the published data on the underlying mechanisms, which can lead to future development of the cardioprotective effect of CH. A better understanding of the CH-activated protective signaling pathways may contribute to new therapeutic approaches in an increase of cardiac tolerance to ischemia/reperfusion.

Keywords: arrhythmias; chronic hypoxia; heart; infarct size; vessels.

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Conflict of interest statement

The authors reported no conflict of interests.

Figures

Figure 1
Figure 1
The possible mechanisms of the antiarrhythmic effect of chronic intermittent hypoxia.
Figure 2
Figure 2
The effect of chronic hypoxia on the level of hormones and humoral factors in the blood and the expression of peptides in the myocardium.
Figure 3
Figure 3
The effect of chronic hypoxia on the cellular and molecular mechanisms.
See this image and copyright information in PMC

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Grants and funding

This work was supported by the Russian Science Foundation grant 22-15-00048. The section dedicated to the role of kinases in the cardioprotective effect of chronic hypoxia is framed within the framework of state assignments 122020300042-4.
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