Chronic inflammation and the hallmarks of aging
- PMID: 37329949
- PMCID: PMC10359950
- DOI: 10.1016/j.molmet.2023.101755
Chronic inflammation and the hallmarks of aging
Abstract
Background: Recently, the hallmarks of aging were updated to include dysbiosis, disabled macroautophagy, and chronic inflammation. In particular, the low-grade chronic inflammation during aging, without overt infection, is defined as "inflammaging," which is associated with increased morbidity and mortality in the aging population. Emerging evidence suggests a bidirectional and cyclical relationship between chronic inflammation and the development of age-related conditions, such as cardiovascular diseases, neurodegeneration, cancer, and frailty. How the crosstalk between chronic inflammation and other hallmarks of aging underlies biological mechanisms of aging and age-related disease is thus of particular interest to the current geroscience research.
Scope of review: This review integrates the cellular and molecular mechanisms of age-associated chronic inflammation with the other eleven hallmarks of aging. Extra discussion is dedicated to the hallmark of "altered nutrient sensing," given the scope of Molecular Metabolism. The deregulation of hallmark processes during aging disrupts the delicate balance between pro-inflammatory and anti-inflammatory signaling, leading to a persistent inflammatory state. The resultant chronic inflammation, in turn, further aggravates the dysfunction of each hallmark, thereby driving the progression of aging and age-related diseases.
Main conclusions: The crosstalk between chronic inflammation and other hallmarks of aging results in a vicious cycle that exacerbates the decline in cellular functions and promotes aging. Understanding this complex interplay will provide new insights into the mechanisms of aging and the development of potential anti-aging interventions. Given their interconnectedness and ability to accentuate the primary elements of aging, drivers of chronic inflammation may be an ideal target with high translational potential to address the pathological conditions associated with aging.
Keywords: Ageing; Aging; Inflammaging; Inflammation; Nutrient sensing; Senescence.
Copyright © 2023 The Authors. Published by Elsevier GmbH.. All rights reserved.
Conflict of interest statement
Declaration of competing interest DF is co-founder and & Chairman of the Scientific Advisory Board of Edifice Health, a company that utilizes Inflammatory Age (iAge) to quantify chronic inflammation and immune health. The remaining authors declare no competing interests.
Figures
![Figure 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/10359950/bin/gr1.gif)
![Figure 2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/10359950/bin/gr2.gif)
![Figure 3](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/10359950/bin/gr3.gif)
Similar articles
-
Magnesium and the Hallmarks of Aging.Nutrients. 2024 Feb 9;16(4):496. doi: 10.3390/nu16040496. Nutrients. 2024. PMID: 38398820 Free PMC article. Review.
-
Meta-hallmarks of aging and cancer.Cell Metab. 2023 Jan 3;35(1):12-35. doi: 10.1016/j.cmet.2022.11.001. Cell Metab. 2023. PMID: 36599298 Review.
-
Cold-inflammaging: When a state of homeostatic-imbalance associated with aging precedes the low-grade pro-inflammatory-state (inflammaging): Meaning, evolution, inflammaging phenotypes.Clin Exp Pharmacol Physiol. 2022 Sep;49(9):925-934. doi: 10.1111/1440-1681.13686. Epub 2022 Jul 4. Clin Exp Pharmacol Physiol. 2022. PMID: 35684970 Review.
-
Hallmarks of aging: An expanding universe.Cell. 2023 Jan 19;186(2):243-278. doi: 10.1016/j.cell.2022.11.001. Epub 2023 Jan 3. Cell. 2023. PMID: 36599349 Review.
-
Zbp1 gene: a modulator of multiple aging hallmarks as potential therapeutic target for age-related diseases.Biogerontology. 2023 Dec;24(6):831-844. doi: 10.1007/s10522-023-10039-w. Epub 2023 May 18. Biogerontology. 2023. PMID: 37199888 Review.
Cited by
-
Integrating transcriptomics and metabolomics to reveal the protective effect and mechanism of Bushen Kangshuai Granules on the elderly people.Front Pharmacol. 2024 Jul 29;15:1361284. doi: 10.3389/fphar.2024.1361284. eCollection 2024. Front Pharmacol. 2024. PMID: 39135783 Free PMC article.
-
Phytonutrients in the promotion of healthspan: a new perspective.Front Nutr. 2024 Jul 12;11:1409339. doi: 10.3389/fnut.2024.1409339. eCollection 2024. Front Nutr. 2024. PMID: 39070259 Free PMC article. Review.
-
Safety of Gonadal Tissue-Derived Mesenchymal Stem Cell Therapy in Geriatric Dogs with Chronic Disease.Animals (Basel). 2024 Jul 22;14(14):2134. doi: 10.3390/ani14142134. Animals (Basel). 2024. PMID: 39061596 Free PMC article.
-
Telomere Length in a South African Population Co-Infected with HIV and Helminths.Curr Issues Mol Biol. 2024 Jul 2;46(7):6853-6867. doi: 10.3390/cimb46070409. Curr Issues Mol Biol. 2024. PMID: 39057051 Free PMC article.
-
The Influence of Social Dynamics on Biological Aging and the Health of Historically Marginalized Populations: A Biopsychosocial Model for Health Disparities.Int J Environ Res Public Health. 2024 Apr 26;21(5):554. doi: 10.3390/ijerph21050554. Int J Environ Res Public Health. 2024. PMID: 38791769 Free PMC article. Review.
References
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Research Materials