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Review
. 2023 Aug;23(8):471-479.
doi: 10.1007/s11882-023-01088-9. Epub 2023 Jul 12.

Autoimmune Inflammatory Eye Disease: Demystifying Clinical Presentations for the Internist

Richmond Woodward  1 , Sri Meghana Konda  1 , Dilraj S Grewal  2
Affiliations
Review

Autoimmune Inflammatory Eye Disease: Demystifying Clinical Presentations for the Internist

Richmond Woodward et al. Curr Allergy Asthma Rep. 2023 Aug.

Abstract

Purpose of review: Provide a framework for recognizing key symptoms and clinical findings in patients with autoimmune inflammatory eye disease.

Recent findings: The most common manifestations of autoimmune inflammatory eye disease are episcleritis, scleritis, uveitis (anterior, intermediate, posterior, and panuveitis), and keratoconjunctivitis sicca. Etiologies can be idiopathic or in association with a systemic autoimmune condition. Referral of patients who may have scleritis is critical for patients presenting with red eyes. Referral of patients who may have uveitis is critical for patients presenting often with floaters and vision complaints. Attention should also be directed to aspects of the history that might suggest a diagnosis of a systemic autoimmune condition, immunosuppression, drug-induced uveitis, or the possibility of a masquerade condition. Infectious etiologies should be ruled out in all cases. Patients with autoimmune inflammatory eye disease may present with ocular or systemic symptoms alone, or in combination. Collaboration with ophthalmologists and other relevant specialists is vital to optimal long-term medical care.

Keywords: Autoimmune eye disease; Episcleritis; Keratoconjunctivitis sicca; Ocular manifestations; Scleritis; Uveitis.

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References

Papers of particular interest, published recently, have been highlighted as: •  Of importance •• Of major importance
    1. Nussenblatt RB, Whitcup SM. Uveitis: fundamentals and clinical practice. 4th ed. Mosby: Elsevier; 2010.
    1. Ness T, Boehringer D, Heinzelmann S. Intermediate uveitis: pattern of etiology, complications, treatment and outcome in a tertiary academic center. Orphanet J Rare Dis. 2017;12(1):81. https://doi.org/10.1186/s13023-017-0638-9 . - DOI - PubMed - PMC
    1. Zlatanovic G, Veselinovic D, Cekic S, et al. Ocular manifestation of rheumatoid arthritis-different forms and frequency. Bosn J Basic Med Sci. 2010;10(4):323–7. https://doi.org/10.17305/bjbms.2010.2680 . - DOI - PubMed - PMC
    1. Amador-Patarroyo MJ, Cristina Peñaranda A, Teresa Bernal M. Autoimmune uveitis. In: Anaya JM, Shoenfeld Y, Rojas-Villarraga A, et al., editors. Autoimmunity: from bench to bedside [Internet]. Bogota (Colombia): El Rosario University Press 2013: Chapter 37. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459445/ .
    1. Makunyane P, Mathebula S. Ocular manifestations of HIV and AIDS patients on antiretroviral therapy in a tertiary hospital in South Africa. African Vis Eye Health. 2021;80(1)6. https://doi.org/10.4102/aveh.v80i1.610 .

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