Involvement of histone methylation in the regulation of neuronal death
- PMID: 37544979
- DOI: 10.1007/s13105-023-00978-w
Involvement of histone methylation in the regulation of neuronal death
Abstract
Neuronal death occurs in various physiological and pathological processes, and apoptosis, necrosis, and ferroptosis are three major forms of neuronal death. Neuronal apoptosis, necrosis, and ferroptosis are widely identified to involve the progress of stroke, Parkinson's disease, and Alzheimer's disease. A growing body of evidence has pointed out that neuronal death is tightly associated with expression of related genes and alteration of signaling molecules. In addition, recently, epigenetics has been increasingly focused on as a vital regulatory mechanism for neuronal apoptosis, necrosis, and ferroptosis, providing a new direction for treating nervous system diseases. Moreover, growing researches suggest that histone methylation or demethylation is involved in the processes of neuronal apoptosis, necrosis, and ferroptosis. These researches may imply that studying the potential roles of histone methylation is essential for treating the nervous system diseases. Here, we review potential roles of histone methylation and demethylation in neuronal death, which may give us a new direction in treating the nervous system diseases.
Keywords: Apoptosis; Ferroptosis; Histone demethylation; Histone methylation; Necrosis.
© 2023. The Author(s) under exclusive licence to University of Navarra.
Similar articles
-
Epigenetic Regulation of Ferroptosis in Central Nervous System Diseases.Mol Neurobiol. 2023 Jul;60(7):3584-3599. doi: 10.1007/s12035-023-03267-1. Epub 2023 Feb 27. Mol Neurobiol. 2023. PMID: 36847936 Review.
-
Neuronal cell death in nervous system development, disease, and injury (Review).Int J Mol Med. 2001 May;7(5):455-78. Int J Mol Med. 2001. PMID: 11295106 Review.
-
Apoptosis and neurologic disease.Am J Med. 2000 Mar;108(4):317-30. doi: 10.1016/s0002-9343(00)00291-6. Am J Med. 2000. PMID: 11014725 Review.
-
Pathophysiological Roles of Intracellular Proteases in Neuronal Development and Neurological Diseases.Mol Neurobiol. 2019 May;56(5):3090-3112. doi: 10.1007/s12035-018-1277-4. Epub 2018 Aug 10. Mol Neurobiol. 2019. PMID: 30097848 Review.
-
Ferroptosis, a Recent Defined Form of Critical Cell Death in Neurological Disorders.J Mol Neurosci. 2018 Oct;66(2):197-206. doi: 10.1007/s12031-018-1155-6. Epub 2018 Aug 25. J Mol Neurosci. 2018. PMID: 30145632 Review.
Cited by
-
Ferroptosis in health and disease.Redox Biol. 2024 Sep;75:103211. doi: 10.1016/j.redox.2024.103211. Epub 2024 May 30. Redox Biol. 2024. PMID: 38908072 Free PMC article. Review.
-
Ferritinophagy: research advance and clinical significance in cancers.Cell Death Discov. 2023 Dec 18;9(1):463. doi: 10.1038/s41420-023-01753-y. Cell Death Discov. 2023. PMID: 38110359 Free PMC article. Review.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical