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Review
. 2023 Aug 20;24(16):12995.
doi: 10.3390/ijms241612995.

Lessons from Animal Models in Sjögren's Syndrome

Diana Mieliauskaitė  1 , Vilius Kontenis  1 , Almantas Šiaurys  2
Affiliations
Review

Lessons from Animal Models in Sjögren's Syndrome

Diana Mieliauskaitė et al. Int J Mol Sci. .

Abstract

Primary Sjögren's syndrome (pSS) is a connective tissue disease characterized by a wide spectrum of clinical features, extending from a benign glandular disease to an aggressive systemic disorder and/or lymphoma. The pathogenesis of Sjögren's syndrome (SS) is not completely understood, but it is assumed that pathogenesis of SS is multifactorial. The studies based on the animal models of SS provided significant insight in SS disease pathogenesis and management. The aim of this review is to summarize current studies on animal models with primary SS-like symptoms and discuss the impact of these studies on better understanding pathogenesis and management of Sjögren's syndrome. Databases PubMed, Web of Science, Scopus and Cochrane library were searched for summarizing studies on animal models in SS. Available data demonstrate that animal models are highly important for our understanding of SS disease.

Keywords: Sjögren’s syndrome; animal models; genetic mouse model; humanized mouse model; induced mouse model; microbiome; microbiota.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Contribution of gastrointestinal microbiome to Sjögren’s syndrome by molecular mimicry.
Figure 2
Figure 2
Contribution of the gastrointestinal microbiome to Sjögren’s syndrome by chronic local gut mucosal inflammation.
See this image and copyright information in PMC

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