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Meta-Analysis
. 2023 Nov;35(11):2307-2321.
doi: 10.1007/s40520-023-02546-0. Epub 2023 Sep 7.

The application of saccades to assess cognitive impairment among older adults: a systematic review and meta-analysis

Shifang Zhang  1 , Xiuxiu Huang  1 , Ran An  1 , Weizhong Xiao  2 , Qiaoqin Wan  3
Affiliations
Meta-Analysis

The application of saccades to assess cognitive impairment among older adults: a systematic review and meta-analysis

Shifang Zhang et al. Aging Clin Exp Res. 2023 Nov.

Abstract

Background: Saccade is a novel and feasible method for cognition assessment and has potential to screen older people with cognitive impairment.

Objectives: To systematically summarize the evidence and determine whether different saccade parameters can effectively identify patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD).

Methods: English and Chinese databases were searched until 19 April 2022. Studies analyzing saccade parameters in older adults with normal cognition, MCI, or AD were included. Two researchers independently performed the screening, data extraction, and quality appraisal. Meta-analyses were conducted and standard mean differences and 95% confidence intervals were estimated with a random effects model.

Results: Thirty-five studies were included, and 26 studies were pooled for the meta-analysis. The results demonstrated that patients with cognitive impairment exhibited longer latency and lower accuracy rates in the prosaccade and antisaccade tasks, along with lower corrected error rates in the antisaccade tasks. However, the pooled results for antisaccades were more stable, providing the ability to distinguish patients with cognitive impairment among older adults. The results of the subgroup analyses revealed that only the accuracy rates of the antisaccades differed significantly between people with MCI and AD. Regarding the differences between older adults with normal cognition and those with MCI, the effect sizes of latency and the accuracy rates of saccades as well as the corrected error rates of antisaccades were significant.

Conclusions: Saccades, especially antisaccades, are a potential screening and assessment tool for distinguishing older adults with MCI or AD from those with normal cognition.

Keywords: Cognitive impairment; Dementia; Eye tracking; Saccade; Systematic review.

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References

    1. Jia L, Quan M, Fu Y et al (2020) Dementia in China: epidemiology, clinical management, and research advances. Lancet Neurol 19:81–92. https://doi.org/10.1016/s1474-4422(19)30290-x - DOI - PubMed
    1. World Health Organization (2021) Global status report on the public health response to dementia. World Health Organization Web. https://apps.who.int/iris/bitstream/handle/10665/344701/9789240033245-en...
    1. Whitehead JC, Gambino SA, Richter JD et al (2015) Focus group reflections on the current and future state of cognitive assessment tools in geriatric health care. Neuropsychiatr Dis Treat 11:1455–1466. https://doi.org/10.2147/ndt.s82881 - DOI - PubMed - PMC
    1. Wang Z, Dong B (2018) Screening for cognitive impairment in geriatrics. Clin Geriatr Med 34:515–536. https://doi.org/10.1016/j.cger.2018.06.004 - DOI - PubMed
    1. Zhuang L, Yang Y, Gao J (2021) Cognitive assessment tools for mild cognitive impairment screening. J Neurol 268:1615–1622. https://doi.org/10.1007/s00415-019-09506-7 - DOI - PubMed

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