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. 2023 Aug 31;19(4):72.
doi: 10.3892/br.2023.1654. eCollection 2023 Oct.

Safety of entecavir antiviral therapyduring an accidental pregnancy in patients with chronic hepatitis B

Lihua Cao  1 , Shiwu Li  1 , Jingchao Dong  1 , Jingkui Wen  1 , Lina Ding  1 , Yahui Ge  1 , Qing Yang  2 , Xiaoyuan Xu  3 , Hui Zhuang  4
Affiliations

Safety of entecavir antiviral therapyduring an accidental pregnancy in patients with chronic hepatitis B

Lihua Cao et al. Biomed Rep. .

Abstract

The present study aimed to investigate the effects of accidental pregnancy CHB patients' reproductive age on their offspring during entecavir (ETV) antiviral therapy. A total of 112 couples were retrospectively enrolled, and they were divided into an observational and control group. A total of 53 couples who had accidental pregnancies while receiving long-term ETV antiviral medication were recruited for the observational group. The control group consisted of 59 couples who became pregnant accidentally while receiving long-term tenofovir disoproxil fumarate (TDF) antiviral treatment. All mothers persisted in their pregnancies in the observational group, and ETV was promptly replaced with TDF. Every mother remained pregnant and continued to use TDF in the control group. The maternal and baby safety profiles, including the prevalence of congenital disabilities, were comparable across the observational and control groups at delivery. In addition, no unusual indications or symptoms of the newborns were noted during the follow-up intervals of 28, 48, and 96 weeks postpartum. Initiating ETV or TDF in early and middle pregnancy seems safe for mothers and infants. Important data from the present study support using ETV in early-mid gestational accidental pregnancies and the prompt substitution of TDF antiviral medication for ETV.

Keywords: accident pregnancy; antiviral therapy; chronic hepatitis B; entecavir; safety; tenofovir disoproxil fumarate.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Enrollment of the participants and the study findings. The observation group had one pair of twins, and the control group all were singleton births.
See this image and copyright information in PMC

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Grants and funding

Funding: The study was supported by The Health Commission of Hebei Province (grant no. GL2014078) and the Qinhuangdao Science and Technology Bureau (grant no. 201801B033).
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