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Review
. 2023 Sep 25;13(1):15965.
doi: 10.1038/s41598-023-43119-5.

Research progress of different components of PM2.5 and ischemic stroke

Bin Li #  1 , Yong Ma #  2 , Yu Zhou #  3 , Erqing Chai  4
Affiliations
Review

Research progress of different components of PM2.5 and ischemic stroke

Bin Li et al. Sci Rep. .

Abstract

PM2.5 is a nonhomogeneous mixture of complex components produced from multiple sources, and different components of this mixture have different chemical and biological toxicities, which results in the fact that the toxicity and hazards of PM2.5 may vary even for the same mass of PM2.5. Previous studies on PM2.5 and ischemic stroke have reached different or even opposing conclusions, and considering the heterogeneity of PM2.5 has led researchers to focus on the health effects of specific PM2.5 components. However, due to the complexity of PM2.5 constituents, assessing the association between exposure to specific PM2.5 constituents and ischemic stroke presents significant challenges. Therefore, this paper reviews and analyzes studies related to PM2.5 and its different components and ischemic stroke, aiming to understand the composition of PM2.5 and identify its harmful components, elucidate their relationship with ischemic stroke, and thus provide some insights and considerations for studying the biological mechanisms by which they affect ischemic stroke and for the prevention and treatment of ischemic stroke associated with different components of PM2.5.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
The main pathways and possible mechanisms by which PM2.5 and its different components affect ischemic stroke. The different colored balls represent different components of PM2.5, which affects ischemic stroke mainly through the respiratory pathway. The possible mechanisms of ischemic stroke involve the pathways of atherosclerosis, platelet aggregation, genetic mutation, and neural interference et al.
See this image and copyright information in PMC

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