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. 2024 Mar;31(3):773-778.
doi: 10.1007/s43032-023-01354-1. Epub 2023 Oct 10.

Association of Leptin with Glucose Intolerance and Gestational Diabetes Mellitus in Pregnant Women: Prospective Analytical Case-Control Study

Türkan Cengiz  1 , Müfide Öncel  2 , Türkan Toka Özer  3 , Refika Selimoğlu  4 , Aysel Kıyıcı  5 , Handan Yılmaz  6
Affiliations

Association of Leptin with Glucose Intolerance and Gestational Diabetes Mellitus in Pregnant Women: Prospective Analytical Case-Control Study

Türkan Cengiz et al. Reprod Sci. 2024 Mar.

Abstract

This study aimed to investigate the use of leptin as a marker for gestational diabetes by analyzing any correlation between serum leptin levels versus oral glucose tolerance tests (at 24 to 28 weeks of pregnancy) and increased body weight (during pregnancy). A total of 110 female cases (81 pregnant and 29 non-pregnant) were included in the study. The 81 pregnant cases were divided into 3 groups according to their oral glucose tolerance test results. A chi-square test was used for categorical variables. The distribution of numerical variables was tested with the Shapiro-Wilk test. ANOVA and a post-hoc Bonferroni test was used for parametric data. Kruskal-Wallis variance analysis was used for non-parametric data. The Mann-Whitney U-test was used for pairwise comparisons. Spearman correlation analysis and multivariate regression analysis were performed for the evaluation of the correlation analysis between the parameters. Oral glucose tolerance test results were compared with leptin levels with a cut-off value of 11.43 for leptin. The ROC curve demonstrated an 83.3% sensitivity and 72.1% specificity for leptin. Leptin may play a role in the pathophysiology of gestational diabetes mellitus. However, the relationship between leptin levels and maternal weight gain during pregnancy is still unknown.

Keywords: Diabetes; Gestational; Glucose tolerance test; Leptin.

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References

    1. Engelgau MM, Herman WH, Smith PJ, German RR, Aubert RE. The epidemiology of diabetes and pregnancy in the US., 1988. Diabetes Care. 1995;18(7):1029–33. - DOI - PubMed
    1. Yalçın HR, Zorlu CG. Threshold value of glucoses creening tests in pregnancy: could it be standardized for every population? Am J Perinatol. 1996;13(5):317–20. - DOI - PubMed
    1. Tanır HM, Sener T, Gürer H, Kaya M. A ten-year gestational diabetes mellitus cohort at a university clinic of mid-Anatolian region of Turkey. Clin Exp Obstet Gynecol. 2005;32(4):241–4. - PubMed
    1. Öncül M, Uludağ S, Şen C, et al. The role of maternal serum leptin and malondialdehyde levels in screening and diagnosis of gestational diabetes mellitus. Perinatol Journal. 2009;17(1). http://www.perinataljournal.com/20090171003
    1. Uludağ S, Gezer A. Gebelik diyabeti. TJOD-Uzmanlık sonrası eğitim ve güncel gelişmeler. 2005;2:55–61.

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