Winding Down the Storm: Could Empagliflozin's Ion-Dependent Mechanisms Tackle the Ventricular Arrhythmia Burden in Chronic Chagas Cardiomyopathy?

doi:10.1007/s10557-023-07510-8

. 2024 Feb;38(1):203-205.

doi: 10.1007/s10557-023-07510-8. Epub 2023 Oct 16.

Winding Down the Storm: Could Empagliflozin's Ion-Dependent Mechanisms Tackle the Ventricular Arrhythmia Burden in Chronic Chagas Cardiomyopathy?

Sergio Alejandro Gómez-Ochoa^{1

2}, Lyda Z Rojas³, Luis Eduardo Echeverría⁴

Affiliations

¹ Heart Failure and Transplant Clinic, Fundación Cardiovascular de Colombia, Calle 155A # 23-58 Urbanización El Bosque, PO. Box 681001, Floridablanca, Colombia.
² Department of General Internal Medicine and Psychosomatics, Heidelberg University Hospital, Heidelberg, Germany.
³ Research Group and Development of Nursing Knowledge (GIDCEN-FCV), Research Center, Fundación Cardiovascular de Colombia, Calle 155A # 23-58 Urbanización El Bosque, PO. Box 681001, Floridablanca, Colombia.
⁴ Heart Failure and Transplant Clinic, Fundación Cardiovascular de Colombia, Calle 155A # 23-58 Urbanización El Bosque, PO. Box 681001, Floridablanca, Colombia. luisecheverria@fcv.org.

PMID: 37843718
DOI: 10.1007/s10557-023-07510-8

Winding Down the Storm: Could Empagliflozin's Ion-Dependent Mechanisms Tackle the Ventricular Arrhythmia Burden in Chronic Chagas Cardiomyopathy?

Sergio Alejandro Gómez-Ochoa et al. Cardiovasc Drugs Ther. 2024 Feb.

. 2024 Feb;38(1):203-205.

doi: 10.1007/s10557-023-07510-8. Epub 2023 Oct 16.

Authors

Sergio Alejandro Gómez-Ochoa^{1

2}, Lyda Z Rojas³, Luis Eduardo Echeverría⁴

Affiliations

¹ Heart Failure and Transplant Clinic, Fundación Cardiovascular de Colombia, Calle 155A # 23-58 Urbanización El Bosque, PO. Box 681001, Floridablanca, Colombia.
² Department of General Internal Medicine and Psychosomatics, Heidelberg University Hospital, Heidelberg, Germany.
³ Research Group and Development of Nursing Knowledge (GIDCEN-FCV), Research Center, Fundación Cardiovascular de Colombia, Calle 155A # 23-58 Urbanización El Bosque, PO. Box 681001, Floridablanca, Colombia.
⁴ Heart Failure and Transplant Clinic, Fundación Cardiovascular de Colombia, Calle 155A # 23-58 Urbanización El Bosque, PO. Box 681001, Floridablanca, Colombia. luisecheverria@fcv.org.

PMID: 37843718
DOI: 10.1007/s10557-023-07510-8

No abstract available

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References

1. Peng X, Li L, Lin R, et al. Empagliflozin ameliorates ouabain-induced Na+ and Ca2+ dysregulations in ventricular myocytes in an Na+-dependent manner. Cardiovasc Drugs Ther. 2023;37:461–9. - DOI - PubMed
1. Nunes MCP, Beaton A, Acquatella H, et al. Chagas cardiomyopathy: an update of current clinical knowledge and management: a scientific statement from the American Heart Association. Circulation. 2018;138:e169–209. - DOI - PubMed
1. Bögeholz N, Pauls P, Bauer BK, et al. Overexpression of the Na+ /Ca2+ exchanger influences ouabain-mediated spontaneous Ca2+ activity but not positive inotropy. Fundam Clin Pharmacol. 2019;33:43–51. - DOI - PubMed
1. Li H-L, Lip GYH, Feng Q, et al. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and cardiac arrhythmias: a systematic review and meta-analysis. Cardiovasc Diabetol. 2021;20:100. - DOI - PubMed - PMC
1. Santos-Miranda A, Joviano-Santos JV, Sarmento JO, et al. A novel substrate for arrhythmias in Chagas disease. PLoS Negl Trop Dis. 2021;15:e0009421. - DOI - PubMed - PMC

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[1] Peng X, Li L, Lin R, et al. Empagliflozin ameliorates ouabain-induced Na+ and Ca2+ dysregulations in ventricular myocytes in an Na+-dependent manner. Cardiovasc Drugs Ther. 2023;37:461–9. - DOI - PubMed

[2] Peng X, Li L, Lin R, et al. Empagliflozin ameliorates ouabain-induced Na+ and Ca2+ dysregulations in ventricular myocytes in an Na+-dependent manner. Cardiovasc Drugs Ther. 2023;37:461–9. - DOI - PubMed

[3] Nunes MCP, Beaton A, Acquatella H, et al. Chagas cardiomyopathy: an update of current clinical knowledge and management: a scientific statement from the American Heart Association. Circulation. 2018;138:e169–209. - DOI - PubMed

[4] Nunes MCP, Beaton A, Acquatella H, et al. Chagas cardiomyopathy: an update of current clinical knowledge and management: a scientific statement from the American Heart Association. Circulation. 2018;138:e169–209. - DOI - PubMed

[5] Bögeholz N, Pauls P, Bauer BK, et al. Overexpression of the Na+ /Ca2+ exchanger influences ouabain-mediated spontaneous Ca2+ activity but not positive inotropy. Fundam Clin Pharmacol. 2019;33:43–51. - DOI - PubMed

[6] Bögeholz N, Pauls P, Bauer BK, et al. Overexpression of the Na+ /Ca2+ exchanger influences ouabain-mediated spontaneous Ca2+ activity but not positive inotropy. Fundam Clin Pharmacol. 2019;33:43–51. - DOI - PubMed

[7] Li H-L, Lip GYH, Feng Q, et al. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and cardiac arrhythmias: a systematic review and meta-analysis. Cardiovasc Diabetol. 2021;20:100. - DOI - PubMed - PMC

[8] Li H-L, Lip GYH, Feng Q, et al. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and cardiac arrhythmias: a systematic review and meta-analysis. Cardiovasc Diabetol. 2021;20:100. - DOI - PubMed - PMC

[9] Santos-Miranda A, Joviano-Santos JV, Sarmento JO, et al. A novel substrate for arrhythmias in Chagas disease. PLoS Negl Trop Dis. 2021;15:e0009421. - DOI - PubMed - PMC

[10] Santos-Miranda A, Joviano-Santos JV, Sarmento JO, et al. A novel substrate for arrhythmias in Chagas disease. PLoS Negl Trop Dis. 2021;15:e0009421. - DOI - PubMed - PMC

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Winding Down the Storm: Could Empagliflozin's Ion-Dependent Mechanisms Tackle the Ventricular Arrhythmia Burden in Chronic Chagas Cardiomyopathy?

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Winding Down the Storm: Could Empagliflozin's Ion-Dependent Mechanisms Tackle the Ventricular Arrhythmia Burden in Chronic Chagas Cardiomyopathy?

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