Association between maternal exposure to arsenic by drinking water during pregnancy and risk of preterm birth: a systematic review and meta-analysis

doi:10.1080/09603123.2023.2280155

Review

. 2024 Aug;34(8):2947-2956.

doi: 10.1080/09603123.2023.2280155. Epub 2023 Nov 15.

Association between maternal exposure to arsenic by drinking water during pregnancy and risk of preterm birth: a systematic review and meta-analysis

Ria Margiana^{1

2

3

4}, Shadia Hamoud Alshahrani⁵, Dilrabo Kayumova⁶, Ahmed Hussien Radie Alawadi^{7

8}, Ahmed Hjazi⁹, Ali Alsalamy¹⁰, Qutaiba A Qasim¹¹, Ashima Juyal¹², Nazila Garousi¹³

Affiliations

¹ Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
² Master's Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
³ Andrology Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
⁴ Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
⁵ Medical Surgical Nursing Department, King Khalid University, Khamis Mushate, Saudi Arabia.
⁶ Department of Obstetrics and Gynecology, Tashkent Medical Academy, Tashkent, Uzbekistan.
⁷ College of technical engineering, the Islamic University, Najaf, Iraq.
⁸ College of technical engineering, the Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq.
⁹ Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia.
¹⁰ College of technical engineering, Imam Ja'afar Al-Sadiq University, Al-Muthanna, Iraq.
¹¹ College of pharmacy, Al-Ayen University, Thi-Qar, Iraq.
¹² Electronics & Communication engineering, Uttaranchal Institute of Technology, Uttaranchal University, Dehradun, India.
¹³ Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.

PMID: 37967266
DOI: 10.1080/09603123.2023.2280155

Review

Association between maternal exposure to arsenic by drinking water during pregnancy and risk of preterm birth: a systematic review and meta-analysis

Ria Margiana et al. Int J Environ Health Res. 2024 Aug.

. 2024 Aug;34(8):2947-2956.

doi: 10.1080/09603123.2023.2280155. Epub 2023 Nov 15.

Authors

Affiliations

¹ Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
² Master's Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
³ Andrology Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
⁴ Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
⁵ Medical Surgical Nursing Department, King Khalid University, Khamis Mushate, Saudi Arabia.
⁶ Department of Obstetrics and Gynecology, Tashkent Medical Academy, Tashkent, Uzbekistan.
⁷ College of technical engineering, the Islamic University, Najaf, Iraq.
⁸ College of technical engineering, the Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq.
⁹ Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia.
¹⁰ College of technical engineering, Imam Ja'afar Al-Sadiq University, Al-Muthanna, Iraq.
¹¹ College of pharmacy, Al-Ayen University, Thi-Qar, Iraq.
¹² Electronics & Communication engineering, Uttaranchal Institute of Technology, Uttaranchal University, Dehradun, India.
¹³ Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.

PMID: 37967266
DOI: 10.1080/09603123.2023.2280155

Abstract

The relation of exposure to arsenic in drinking water during pregnancy to the risk of preterm birth (PTB) was contradictory. This meta-analysis aimed to examine the association between drinking water arsenic and PTB. A systematic search in PubMed and Scopus was performed to achieve all relevant studies. Odds ratios (OR) and 95% confidence intervals (CI) were used to pool data using the random-effect models. Overall, 11 studies with a total sample size of 3,404,189 participants were included in the meta-analysis. Arsenic exposure through drinking water during pregnancy was related to an increased risk of PTB (OR = 1.06; 95%CI = 1.01-1.10 for highest versus lowest category of arsenic), with significant heterogeneity across the studies (I² = 84.8%, P = 0.001). This finding was supported by cohort studies (OR = 1.05; 95%CI = 1.01-1.10). This meta-analysis proposes that higher arsenic exposure in drinking water may be a risk factor for PTB.

Keywords: Arsenic; meta-analysis; pregnancy; preterm birth; water.

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Association between maternal exposure to arsenic by drinking water during pregnancy and risk of preterm birth: a systematic review and meta-analysis

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Association between maternal exposure to arsenic by drinking water during pregnancy and risk of preterm birth: a systematic review and meta-analysis

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