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Review
. 2024 Feb 1;436(3):168370.
doi: 10.1016/j.jmb.2023.168370. Epub 2023 Nov 20.

Per-ARNT-Sim (PAS) Domains in Basic Helix-Loop-Helix (bHLH)-PAS Transcription Factors and Coactivators: Structures and Mechanisms

Nicolas Daffern  1 , Ishwar Radhakrishnan  2
Affiliations
Review

Per-ARNT-Sim (PAS) Domains in Basic Helix-Loop-Helix (bHLH)-PAS Transcription Factors and Coactivators: Structures and Mechanisms

Nicolas Daffern et al. J Mol Biol. .

Abstract

PAS domains are ubiquitous in biology. They perform critically important roles in sensing and transducing a wide variety of environmental signals, and through their ability to bind small-molecule ligands, have emerged as targets for therapeutic intervention. Here, we discuss our current understanding of PAS domain structure and function in the context of basic helix-loop-helix (bHLH)-PAS transcription factors and coactivators. Unlike the bHLH-PAS domains of transcription factors, those of the steroid receptor coactivator (SRC) family are poorly characterized. Recent progress for this family and for the broader bHLH-PAS proteins suggest that these domains are ripe for deeper structural and functional studies.

Keywords: protein-DNA interactions; protein–ligand interactions; protein–protein interactions; structural biology; transcription regulation.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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References

    1. Hoffman EC, Reyes H, Chu FF, Sander F, Conley LH, Brooks BA & Hankinson O (1991). Cloning of a factor required for activity of the Ah (dioxin) receptor. Science 252, 954–958. - PubMed
    1. Nambu JR, Lewis JO, Wharton KA Jr. & Crews ST (1991). The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development. Cell 67, 1157–1167. - PubMed
    1. Moglich A, Ayers RA & Moffat K (2009). Structure and signaling mechanism of Per-ARNT-Sim domains. Structure 17, 1282–1294. - PMC - PubMed
    1. Henry JT & Crosson S (2011). Ligand-binding PAS domains in a genomic, cellular, and structural context. Annu. Rev. Microbiol 65, 261–286. - PMC - PubMed
    1. Rost B (1999). Twilight zone of protein sequence alignments. Protein Eng. 12, 85–94. - PubMed

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