Procyanidin alleviates ferroptosis and inflammation of LPS-induced RAW264.7 cell via the Nrf2/HO-1 pathway

doi:10.1007/s00210-023-02854-2

. 2024 Jun;397(6):4055-4067.

doi: 10.1007/s00210-023-02854-2. Epub 2023 Nov 27.

Procyanidin alleviates ferroptosis and inflammation of LPS-induced RAW264.7 cell via the Nrf2/HO-1 pathway

Jiayan Zeng^#¹, Yanmin Weng^#¹, Tianli Lai^#¹, Lan Chen¹, Ying Li¹, Qiqi Huang¹, Saiyi Zhong², Shibiao Wan³, Lianxiang Luo^{4

5}

Affiliations

¹ The First Clinical College, Guangdong Medical University, Zhanjiang, 524023, Guangdong, China.
² Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, 524088, China.
³ Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA. swan@unmc.edu.
⁴ The Marine Biomedical Research Institute, Guangdong Medical University, No. 2 Wenming East Road, Xiashan District, Zhanjiang, 524023, Guangdong, China. luolianxiang321@gdmu.edu.cn.
⁵ The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang, Guangdong, 524023, China. luolianxiang321@gdmu.edu.cn.

^# Contributed equally.

PMID: 38010399
DOI: 10.1007/s00210-023-02854-2

Procyanidin alleviates ferroptosis and inflammation of LPS-induced RAW264.7 cell via the Nrf2/HO-1 pathway

Jiayan Zeng et al. Naunyn Schmiedebergs Arch Pharmacol. 2024 Jun.

. 2024 Jun;397(6):4055-4067.

doi: 10.1007/s00210-023-02854-2. Epub 2023 Nov 27.

Authors

Jiayan Zeng^#¹, Yanmin Weng^#¹, Tianli Lai^#¹, Lan Chen¹, Ying Li¹, Qiqi Huang¹, Saiyi Zhong², Shibiao Wan³, Lianxiang Luo^{4

5}

Affiliations

¹ The First Clinical College, Guangdong Medical University, Zhanjiang, 524023, Guangdong, China.
² Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, 524088, China.
³ Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA. swan@unmc.edu.
⁴ The Marine Biomedical Research Institute, Guangdong Medical University, No. 2 Wenming East Road, Xiashan District, Zhanjiang, 524023, Guangdong, China. luolianxiang321@gdmu.edu.cn.
⁵ The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang, Guangdong, 524023, China. luolianxiang321@gdmu.edu.cn.

^# Contributed equally.

PMID: 38010399
DOI: 10.1007/s00210-023-02854-2

Abstract

Inflammation is a common occurrence in many medical conditions and is a natural defense mechanism of the human body. Ferroptosis, an iron-dependent form of cell death related to lipid peroxide build-up, has been found to be involved in inflammation. The anti-inflammatory effects of procyanidin, however, are not yet fully understood. Through network pharmacology and bioinformatics analysis, it was suggested that procyanidin could modulate ferroptosis and cause anti-inflammatory effects on RAW264.7 cells. This was further evidenced through molecular docking, molecular dynamics, and in vitro experiments. The results indicated that procyanidin could diminish inflammation in LPS-induced RAW264.7 cells by regulating ferroptosis via the Nrf2/HO-1/Keap-1 pathway. In conclusion, procyanidin supplementation might be an effective way to reduce inflammation by decreasing the release of inflammatory cytokines and suppressing ferroptosis.

Keywords: Ferroptosis; Inflammation; Nrf2/HO-1/Keap-1 pathway; Procyanidin.

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References

1. Alhouayek M, Muccioli GG (2014) COX-2-derived endocannabinoid metabolites as novel inflammatory mediators. Trends Pharmacol Sci 35:284–292 - PubMed - DOI
1. Arbiser JL, Bonner MY, Ward N, Elsey J, Rao S (2018) Selenium unmasks protective iron armor: a possible defense against cutaneous inflammation and cancer. Biochim Biophys Acta Gen Subj 1862:2518–2527 - PubMed - PMC - DOI
1. Bagchi D, Garg A, Krohn RL, Bagchi M, Tran MX, Stohs SJ (1997) Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro. Res Commun Mol Pathol Pharmacol 95:179–189 - PubMed
1. Buendia I, Michalska P, Navarro E, Gameiro I, Egea J, León R (2016) Nrf2-ARE pathway: an emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases. Pharmacol Ther 157:84–104 - PubMed - DOI
1. Byun MW (2012) Effect of procyanidin C1 on nitric oxide production and hyperpolarization through Ca(2+)-dependent pathway in endothelial cells. J Med Food 15:1032–1037 - PubMed - DOI

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[1] Alhouayek M, Muccioli GG (2014) COX-2-derived endocannabinoid metabolites as novel inflammatory mediators. Trends Pharmacol Sci 35:284–292 - PubMed - DOI

[2] Alhouayek M, Muccioli GG (2014) COX-2-derived endocannabinoid metabolites as novel inflammatory mediators. Trends Pharmacol Sci 35:284–292 - PubMed - DOI

[3] Arbiser JL, Bonner MY, Ward N, Elsey J, Rao S (2018) Selenium unmasks protective iron armor: a possible defense against cutaneous inflammation and cancer. Biochim Biophys Acta Gen Subj 1862:2518–2527 - PubMed - PMC - DOI

[4] Arbiser JL, Bonner MY, Ward N, Elsey J, Rao S (2018) Selenium unmasks protective iron armor: a possible defense against cutaneous inflammation and cancer. Biochim Biophys Acta Gen Subj 1862:2518–2527 - PubMed - PMC - DOI

[5] Bagchi D, Garg A, Krohn RL, Bagchi M, Tran MX, Stohs SJ (1997) Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro. Res Commun Mol Pathol Pharmacol 95:179–189 - PubMed

[6] Bagchi D, Garg A, Krohn RL, Bagchi M, Tran MX, Stohs SJ (1997) Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro. Res Commun Mol Pathol Pharmacol 95:179–189 - PubMed

[7] Buendia I, Michalska P, Navarro E, Gameiro I, Egea J, León R (2016) Nrf2-ARE pathway: an emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases. Pharmacol Ther 157:84–104 - PubMed - DOI

[8] Buendia I, Michalska P, Navarro E, Gameiro I, Egea J, León R (2016) Nrf2-ARE pathway: an emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases. Pharmacol Ther 157:84–104 - PubMed - DOI

[9] Byun MW (2012) Effect of procyanidin C1 on nitric oxide production and hyperpolarization through Ca(2+)-dependent pathway in endothelial cells. J Med Food 15:1032–1037 - PubMed - DOI

[10] Byun MW (2012) Effect of procyanidin C1 on nitric oxide production and hyperpolarization through Ca(2+)-dependent pathway in endothelial cells. J Med Food 15:1032–1037 - PubMed - DOI

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Procyanidin alleviates ferroptosis and inflammation of LPS-induced RAW264.7 cell via the Nrf2/HO-1 pathway

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Procyanidin alleviates ferroptosis and inflammation of LPS-induced RAW264.7 cell via the Nrf2/HO-1 pathway

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