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Review
. 2023 Dec 7;32(1):15.
doi: 10.1007/s00520-023-08229-w.

Effects of unimodal or multimodal prehabilitation on patients undergoing surgery for esophagogastric cancer: a systematic review and meta-analysis

Bingyan Zhao  1 , Tongyu Zhang  1 , Yu Chen  1 , Chunmei Zhang  2
Affiliations
Review

Effects of unimodal or multimodal prehabilitation on patients undergoing surgery for esophagogastric cancer: a systematic review and meta-analysis

Bingyan Zhao et al. Support Care Cancer. .

Abstract

Purpose: To evaluate the effects of unimodal or multimodal prehabilitation on patients undergoing surgery for esophagogastric cancer.

Methods: We conducted a systematic search of the PubMed, Embase, CINAHL, Web of Science, and Cochrane Library (CENTRAL) databases from database inception to May 5, 2023, for randomized controlled trials (RCTs) and cohort studies that investigated prehabilitation in the context of esophagogastric cancer. A random-effects model was used for meta-analysis.

Results: We identified 2,994 records and eventually included 12 studies (6 RCTs and 6 cohort studies) with a total of 910 patients. According to random-effects pooled estimates, prehabilitation reduced the incidence of all complications (RR = 0.79, 95% CI: 0.66 to 0.93, P = 0.006), pulmonary complications (RR = 0.61, 95% CI: 0.47 to 0.79, P = 0.0002), and severe complications (RR = 0.63, 95% CI: 0.47 to 0.84, P = 0.002), and shortened the length of stay (MD = -1.92, 95% CI: -3.11 to -0.73, P = 0.002) compared to usual care. However, there were no statistically significant differences in 30-day readmission rates or in-hospital mortality. Subgroup analysis showed that multimodal prehabilitation was effective in reducing the risk of all complications and severe complications, while unimodal prehabilitation was not.

Conclusions: Our findings suggested that prehabilitation may be beneficial in reducing postoperative complications and length of stay. We recommend preoperative prehabilitation to improve postoperative outcomes and hasten recovery following esophagogastric cancer surgery, and multimodal prehabilitation seems to be more advantageous in reducing complications. However, further studies are needed to confirm these results.

Keywords: Esophagogastric cancer; Exercise; Length of stay; Postoperative complications; Prehabilitation.

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References

    1. Sung H, Ferlay J, Siegel RL et al (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 71:209–249. https://doi.org/10.3322/caac.21660 - DOI - PubMed
    1. J Ferlay, M Ervik, F Lam et al (2020) Global Cancer Observatory: Cancer Today. International Agency for Research on Cancer. https://gco.iarc.fr/today/home . Accessed 15 May 2023
    1. Morgan E, Soerjomataram I, Rumgay H et al (2022) The global landscape of esophageal squamous cell carcinoma and esophageal adenocarcinoma incidence and mortality in 2020 and projections to 2040: new estimates from GLOBOCAN 2020. Gastroenterology 163:649-658.e2. https://doi.org/10.1053/j.gastro.2022.05.054 - DOI - PubMed
    1. Ajani JA, D’Amico TA, Bentrem DJ et al (2023) Esophageal and Esophagogastric Junction Cancers, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw 21:393–422. https://doi.org/10.6004/jnccn.2023.0019 - DOI - PubMed
    1. Ajani JA, D’Amico TA, Bentrem DJ et al (2022) Gastric Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw 20:167–192. https://doi.org/10.6004/jnccn.2022.0008 - DOI - PubMed

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