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Review
. 2023 Dec 15:11:e16633.
doi: 10.7717/peerj.16633. eCollection 2023.

The relationship between leptin and periodontitis: a literature review

Zhijiao Guo  1 , Yanhui Peng  1 , Qiaoyu Hu  1 , Na Liu  2 , Qing Liu  1
Affiliations
Review

The relationship between leptin and periodontitis: a literature review

Zhijiao Guo et al. PeerJ. .

Abstract

Leptin is a peptide hormone that regulates energy balance, immune inflammatory response, and bone metabolism. Several studies have demonstrated a relationship between leptin and periodontitis, a local inflammatory disease that progressively weakens the supporting structures of the teeth, eventually leading to tooth loss. This article reviews the existing literature and discusses leptin's basic characteristics, its relationship with periodontitis, and its effects on periodontal tissue metabolism.

Keywords: Inflammatory cytokines; Leptin; Mechanism; Periodontitis.

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Conflict of interest statement

The authors declare that they have no competing interests.

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