Tuning of TRAIL clustering on the surface of nanoscale liposomes by phase separation
- PMID: 38235079
- PMCID: PMC10790813
- DOI: 10.1039/d3na00841j
Tuning of TRAIL clustering on the surface of nanoscale liposomes by phase separation
Abstract
Phase-separated liposomes were used to formulate tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a protein that selectively kills cancer cells while sparing most healthy ones. By controlling the average number of TRAIL molecules per liposome, we demonstrate the ability to tune the formation of TRAIL clusters and their resulting apoptotic activity.
This journal is © The Royal Society of Chemistry.
Conflict of interest statement
The authors have no conflicts of interest to declare.
Figures
![Fig. 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/10790813/bin/d3na00841j-f1.gif)
![Fig. 2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/10790813/bin/d3na00841j-f2.gif)
![Fig. 3](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/10790813/bin/d3na00841j-f3.gif)
Similar articles
-
Bacteriophage-based particles carrying the TNF-related apoptosis-inducing ligand (TRAIL) gene for targeted delivery in hepatocellular carcinoma.Nanoscale. 2024 Mar 28;16(13):6603-6617. doi: 10.1039/d3nr05660k. Nanoscale. 2024. PMID: 38470366 Free PMC article.
-
Nanoscale Organization of TRAIL Trimers using DNA Origami to Promote Clustering of Death Receptor and Cancer Cell Apoptosis.Small. 2023 Jun;19(23):e2206160. doi: 10.1002/smll.202206160. Epub 2023 Mar 8. Small. 2023. PMID: 36890776
-
Thyroid carcinoma cells are resistant to FAS-mediated apoptosis but sensitive to tumor necrosis factor-related apoptosis-inducing ligand.Cancer Res. 2000 Aug 1;60(15):4122-9. Cancer Res. 2000. PMID: 10945619
-
E3 ubiquitin ligases and deubiquitinases as modulators of TRAIL-mediated extrinsic apoptotic signaling pathway.BMB Rep. 2019 Feb;52(2):119-126. doi: 10.5483/BMBRep.2019.52.2.011. BMB Rep. 2019. PMID: 30638181 Free PMC article. Review.
-
The role of apoptosis-inducing receptors of the tumor necrosis factor family in thyroid cancer.J Endocrinol. 2003 Aug;178(2):205-16. doi: 10.1677/joe.0.1780205. J Endocrinol. 2003. PMID: 12904168 Review.
References
Grants and funding
LinkOut - more resources
Full Text Sources