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Review
. 2023 Oct 16;33(3):539-556.
doi: 10.1007/s10068-023-01434-7. eCollection 2024 Feb.

Plant sources, extraction techniques, analytical methods, bioactivity, and bioavailability of sulforaphane: a review

Xiao Men  1 , Xionggao Han  1 , Geon Oh  1 , Ji-Hyun Im  1 , June Seok Lim  1 , Geun Hee Cho  1 , Sun-Il Choi  1 , Ok-Hwan Lee  1
Affiliations
Review

Plant sources, extraction techniques, analytical methods, bioactivity, and bioavailability of sulforaphane: a review

Xiao Men et al. Food Sci Biotechnol. .

Abstract

Sulforaphane (SFN) is an isothiocyanate commonly found in cruciferous vegetables. It is formed via the enzymatic hydrolysis of glucoraphanin by myrosinase. SFN exerts various biological effects, including anti-cancer, anti-oxidation, anti-obesity, and anti-inflammatory effects, and is widely used in functional foods and clinical medicine. However, the structure of SFN is unstable and easily degradable, and its production is easily affected by temperature, pH, and enzyme activity, which limit its application. Hence, several studies are investigating its physicochemical properties, stability, and biological activity to identify methods to increase its content. This article provides a comprehensive review of the plant sources, extraction and analysis techniques, in vitro and in vivo biological activities, and bioavailability of SFN. This article highlights the importance and provides a reference for the research and application of SFN in the future.

Keywords: Bioactivity; Bioavailability; Extraction technology; Plant source; Sulforaphane.

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Conflict of interest statement

Conflict of interestNone of the authors of this study has any financial interest or conflict with industries or parties.

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References

    1. Abukhabta S, Khalil Ghawi S, Karatzas KA, Charalampopoulos D, McDougall G, Allwood JW, Verrall S, Lavery S, Latimer C, Pourshahidi LK, Lawther R, O’Connor G, Rowland I, Gill CIR. Sulforaphane-enriched extracts from glucoraphanin-rich broccoli exert antimicrobial activity against gut pathogens in vitro and innovative cooking methods increase in vivo intestinal delivery of sulforaphane. European Journal of Nutrition. 2021;60:1263–1276. doi: 10.1007/s00394-020-02322-0. - DOI - PMC - PubMed
    1. Ahn YH, Hwang Y, Liu H, Wang XJ, Zhang Y, Stephenson KK, Boronina TN, Cole RN, Dinkova-kostova AT, Talalay P, Cole PA. Electrophilic tuning of the chemoprotective natural product sulforaphane. Proc. Natl. Acad. Sci. 2010;107:9590–9595. doi: 10.1073/pnas.1004104107. - DOI - PMC - PubMed
    1. Alattar A, Alshaman R, Al-Gayyar MM. Therapeutic effects of sulforaphane in ulcerative colitis: Effect on antioxidant activity, mitochondrial biogenesis and DNA polymerization. Redox Report. 2022;27:128–138. doi: 10.1080/13510002.2022.2092378. - DOI - PMC - PubMed
    1. Ameer K, Shahbaz HM, Kwon JH. Green extraction methods for polyphenols from plant matrices and their byproducts: A review. Comprehensive Reviews in Food Science and Food Safety. 2017;16:295–315. doi: 10.1111/1541-4337.12253. - DOI - PubMed
    1. Anand U, Dey A, Chandel AKS, Sanyal R, Mishra A, Pandey DK, Falco VD, Upadhyay A, Kandimalla R, Chaudhary A, Dhanjal JK, Dewanjee S, Vallamkondu J, de la Lastra JMP. Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics. Genes & Diseases. 2022;10:1367–1401. doi: 10.1016/j.gendis.2022.02.007. - DOI - PMC - PubMed

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