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Review
. 2024 Feb;31(10):14367-14387.
doi: 10.1007/s11356-024-32159-7. Epub 2024 Jan 30.

The looming threat of profenofos organophosphate and microbes in action for their sustainable degradation

Aman Raj  1 , Ashwani Kumar  2   3 , Pramod Kumar Khare  4
Affiliations
Review

The looming threat of profenofos organophosphate and microbes in action for their sustainable degradation

Aman Raj et al. Environ Sci Pollut Res Int. 2024 Feb.

Abstract

Organophosphates are the most extensively used class of pesticides to deal with increasing pest diversity and produce more on limited terrestrial areas to feed the ever-expanding global population. Profenofos, an organophosphate group of non-systematic insecticides and acaricides, is used to combat aphids, cotton bollworms, tobacco budworms, beet armyworms, spider mites, and lygus bugs. Profenofos was inducted into the system as a replacement for chlorpyrifos due to its lower toxicity and half-life. It has become a significant environmental concern due to its widespread presence. It accumulates in various environmental components, contaminating food, water, and air. As a neurotoxic poison, it inhibits acetylcholinesterase receptor activity, leading to dizziness, paralysis, and pest death. It also affects other eukaryotes, such as pollinators, birds, mammals, and invertebrates, affecting ecosystem functioning. Microbes directly expose themselves to profenofos and adapt to these toxic compounds over time. Microbes use these toxic compounds as carbon and energy sources and it is a sustainable and economical method to eliminate profenofos from the environment. This article explores the studies and developments in the bioremediation of profenofos, its impact on plants, pollinators, and humans, and the policies and laws related to pesticide regulation. The goal is to raise awareness about the global threat of profenofos and the role of policymakers in managing pesticide mismanagement.

Keywords: Acetylcholinesterase; Bioremediation; Organophosphate; Pesticides; Pollinators; Profenofos.

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