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Review
. 2024 Jan 19:20:101740.
doi: 10.1016/j.bonr.2024.101740. eCollection 2024 Mar.

Applications of honeybee-derived products in bone tissue engineering

Shahla Korani  1 , Naeemeh Khalesi  2 , Mitra Korani  1 , Tannaz Jamialahmadi  3 , Amirhossein Sahebkar  4   5
Affiliations
Review

Applications of honeybee-derived products in bone tissue engineering

Shahla Korani et al. Bone Rep. .

Abstract

Nowadays, there is an increasing prevalence of bone diseases and defects caused by trauma, cancers, infections, and degenerative and inflammatory conditions. The restoration of bone tissue lost due to trauma, fractures, or surgical removal resulting from locally invasive pathologies requires bone regeneration. As an alternative to conventional treatments, sustainable materials based on natural products, such as honeybee-derived products (honey, propolis, royal jelly, bee pollen, beeswax, and bee venom), could be considered. Honeybee-derived products, particularly honey, have long been recognized for their healing properties. There are a mixture of phytochemicals that offer bone protection through their antimicrobial, antioxidant, and anti-inflammatory properties. This review aims to summarize the current evidence regarding the effects of honeybee-derived products on bone regeneration. In conclusion, honey, propolis, royal jelly, beeswax, and bee venom can potentially serve as natural products for promoting bone health.

Keywords: Bee pollen; Bee venom; Beeswax; Bone defect; Bone engineering; Honey; Propolis; Royal jelly.

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Conflict of interest statement

None.

Figures

Unlabelled Image
Graphical abstract
Fig. 1
Fig. 1
Representative propolis and its components (CAPE, quercin, saponin) and royal jelly component (10HDA) effects on important pathways in osteogenesis. Propolis components inhibit RANKL- induced transcription factors NF-κB and NFAT that are essential in osteoclasts differentiation; and induce transcription factors RUNX2 and osterix that are essential in osteoblast differentiation; propolis induce apoptosis in osteoclasts and regulate inflammation; 10-HDA inhibits RANKL-induced NF-κB.
See this image and copyright information in PMC

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