Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Feb 6.
doi: 10.1007/s12011-024-04089-5. Online ahead of print.

Zinc Transporter ZnT1 mRNA Expression Is Negatively Associated with Leptin Serum Concentrations but Is not Associated with Insulin Resistance or Inflammatory Markers in Visceral Adipose Tissue

Ana Karen Torres-Arreola  1   2 , Olga P García  3 , Paulina Estrella-Ibarra  1   4 , Francisco Campos-Maldonado  1   2 , Mariela Camacho-Barron  3 , María Del Carmen Aburto-Fernández  5 , Ricardo Martín Lerma-Alvarado  5 , Adriana Jheny Rodriguez-Méndez  1 , Juan Carlos Solís-Sáinz  1 , Pablo García-Solís  6
Affiliations

Zinc Transporter ZnT1 mRNA Expression Is Negatively Associated with Leptin Serum Concentrations but Is not Associated with Insulin Resistance or Inflammatory Markers in Visceral Adipose Tissue

Ana Karen Torres-Arreola et al. Biol Trace Elem Res. .

Abstract

The aim of this study was to evaluate the relationship between biomarkers of chronic inflammation, insulin resistance, and zinc transporter ZnT1 expression in human visceral adipose tissue. Visceral adipose tissue obtained from 47 adults undergoing laparoscopic surgery for cholecystectomy was used to analyze ZnT1 mRNA expression by RT-qPCR. ZnT1 mRNA levels were compared between subjects with normal weight, overweight, and obesity. A significantly lower ZnT1 expression was observed in overweight and obesity compared with normal-weight subjects (p = 0.0016). Moreover, subjects with normal weight had significantly higher serum zinc concentration (97.7 ± 13.1 mg/L) than subjects with overweight (87.0 ± 12.8 mg/L) and obesity (83.1 ± 6.6 mg/L) (p = 0.002). Pearson test showed a positive correlation between serum zinc concentrations and ZnT1 mRNA expression in visceral adipose tissue (r = 0.323; p = 0.031) and a negative correlation with body mass index (r = - 0.358; p = 0.013). A linear regression model was used to analyze the associations between ZnT1 mRNA expression and serum zinc levels, insulin resistance (HOMA2-IR), serum adipokines (leptin and adiponectin), and serum inflammation biomarkers (tumor necrosis factor alpha, interleukin-6, and C-reactive protein). Interestingly, leptin concentrations were negatively associated with ZnT1 mRNA expression (p = 0.012); however, no significant associations were found for the rest of the analyzed variables. Future research is needed to analyze the causality of negative association between ZntT1 expression in visceral adipose tissue and leptin.

Keywords: Inflammation; Obesity; Zinc; Zinc transporters.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. WHO Consultation on Obesity (1999: Ginebra, Suiza); y Organización Mundial de la Salud. (2000) Obesity: preventing and managing the global epidemic: report of a WHO consultation. Organización Mundial de la Salud. https://apps.who.int/iris/handle/10665/42330 Accessed 21 June 2021.
    1. Scherer T, Lindtner C, Zielinski E, O’hare J, Filatova N, Buettner C (2012) Short term voluntary overfeeding disrupts brain insulin control of adipose tissue lipolysis. J Biol Chem. https://doi.org/10.1074/jbc.M111.307348 - DOI - PubMed - PMC
    1. Shibata R, Ouchi N, Ohashi K, Murohara T (2017) The role of adipokines in cardiovascular disease. J Cardiol. https://doi.org/10.1016/j.jjcc.2017.02.006
    1. Calder PC, Albers R, Antoine JM (2009) Inflammatory disease processes and interactions with nutrition. Br J Nutr. https://doi.org/10.1017/S0007114509377867 - DOI - PubMed
    1. Troche C, Aydeir T, Cousins R (2016) Zinc transporter Slc39a14 regulates inflammatory signaling associated with hypertrophic adiposity. Am J Physiol Endocrinol Metab. https://doi.org/10.1152/ajpendo.00421.2015 - DOI - PubMed

LinkOut - more resources

-