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. 2024 Mar 2;25(5):2926.
doi: 10.3390/ijms25052926.

Increased Circulating Irisin Levels in Kidney Transplant Patients: Is There a Connection with Glycaemic Control?

Beata Bzoma  1 , Agnieszka Kuchta  2 , Kornelia Sałaga-Zaleska  2 , Aleksandra Krzesińska  2 , Gabriela Chyła-Danił  2 , Maciej Jankowski  2 , Alicja Dębska-Ślizień  1
Affiliations

Increased Circulating Irisin Levels in Kidney Transplant Patients: Is There a Connection with Glycaemic Control?

Beata Bzoma et al. Int J Mol Sci. .

Abstract

Irisin is a myokine with potential effects on glucose metabolism and the development of diabetes in humans. We analysed irisin serum levels (ISL) in 47 patients without diabetes before and 1, 2, 3, 4 and 5 weeks after kidney transplantation (KTx). All measurements of irisin before KTx levels were lower than 25 ng/mL (median 8.4 ng/mL). We found an outstanding increase in ISL measured after KTx, reaching more than 1000 times in 44% of patients (HIL-high irisin level group). The increase appeared at the first measurement (one week after KTx). Factors connected to the large growth of ISL were, i.e., BMI > 30 (p = 0.04) and subsequent KTx-second and third (p < 0.001). The global mean blood glucose level during the first two weeks after KTx was significantly lower in the HIL group (p = 0.002), the same as the day-by-day analysed mean fasting and postprandial serum glucose in the first days after KTx. In 12 months of observation, diabetes requiring insulin therapy occurred in the HIL group at a rate of 19%, while in the rest of the patients, the rate was 27%, p = 0.526. Irisin levels increase significantly in some patients after kidney transplantation, accompanied by lower blood glucose levels in the early post-transplant period. Whether an increase in irisin levels results in better glycaemic control remains questionable and requires further research, as well as the relationship between irisin levels and the occurrence of PTDM.

Keywords: glycaemic disturbances; irisin; kidney transplantation.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Irisin serum level in patients before and after KTx in studied group.
Figure 2
Figure 2
Plots of estimated mean with 95% confidence interval in blood glucose level [mg/dL] in patients with and without irisin increase (HIL and LIL group) during 15 days after KTx. (a) Mean fasting blood glucose level; (b) mean postprandial blood glucose level.
Figure 3
Figure 3
Plot of estimated mean with 95% confidence interval in MAP (Mean Arterial Pressure) [mmHg] in patients with and without irisin increase (HIL and LIL group) during 15 days after KTx.
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