Multiple pulmonary cavities in an immunocompetent patient: a case report and literature review
- PMID: 38476447
- PMCID: PMC10930033
- DOI: 10.3389/fmed.2024.1329381
Multiple pulmonary cavities in an immunocompetent patient: a case report and literature review
Abstract
Legionella pneumonia (LP) is a relatively uncommon yet well-known type of atypical community-acquired pneumonia (CAP). It is characterized by a rapid progression to severe pneumonia and can be easily misdiagnosed. In most patients, chest computed tomography (CT) showed patchy infiltration, which may progress to lobar infiltration or even lobar consolidation. While pulmonary cavities are commonly observed in immunocompromised patients with LP, they are considered rare in immunocompetent individuals. Herein, we present a case of LP in an immunocompetent patient with multiple cavities in both lungs. Pathogen detection was performed using metagenomic next-generation sequencing (mNGS). This case highlights the unusual radiographic presentation of LP in an immunocompetent patient and emphasizes the importance of considering LP as a possible diagnosis in patients with pulmonary cavities, regardless of their immune status. Furthermore, the timely utilization of mNGS is crucial for early pathogen identification, as it provides multiple benefits in enhancing the diagnosis and prognosis of LP patients.
Keywords: Legionella; Legionella pneumonia; Legionella pneumophila; immunocompetent patient; metagenomic next-generation sequencing; pulmonary cavity.
Copyright © 2024 Guo, Zuo, Liu, Jiang, Yang and Lu.
Conflict of interest statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Figures
![Figure 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/10930033/bin/fmed-11-1329381-g001.gif)
![Figure 2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/10930033/bin/fmed-11-1329381-g002.gif)
![Figure 3](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/10930033/bin/fmed-11-1329381-g003.gif)
![Figure 4](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/10930033/bin/fmed-11-1329381-g004.gif)
![Figure 5](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/10930033/bin/fmed-11-1329381-g005.gif)
Similar articles
-
Case Report: Community-Acquired Legionella gormanii Pneumonia in an Immunocompetent Patient Detected by Metagenomic Next-Generation Sequencing.Front Med (Lausanne). 2022 Jan 28;9:819425. doi: 10.3389/fmed.2022.819425. eCollection 2022. Front Med (Lausanne). 2022. PMID: 35155502 Free PMC article.
-
Metagenomic next-generation sequencing clinches the diagnosis of Legionella pneumonia in a patient with acute myeloid leukemia: A case report and literature review.Front Cell Infect Microbiol. 2022 Nov 21;12:924597. doi: 10.3389/fcimb.2022.924597. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 36478673 Free PMC article. Review.
-
Case Report: Metagenomic Next-Generation Sequencing in Diagnosis of Legionella pneumophila Pneumonia in a Patient After Umbilical Cord Blood Stem Cell Transplantation.Front Med (Lausanne). 2021 Jun 11;8:643473. doi: 10.3389/fmed.2021.643473. eCollection 2021. Front Med (Lausanne). 2021. PMID: 34179036 Free PMC article.
-
Case report: Fatal Legionella infection diagnosed via by metagenomic next-generation sequencing in a patient with chronic myeloid leukemia.Front Med (Lausanne). 2023 Nov 22;10:1266895. doi: 10.3389/fmed.2023.1266895. eCollection 2023. Front Med (Lausanne). 2023. PMID: 38076254 Free PMC article.
-
Early Detection of Legionella pneumophila and Aspergillus by mNGS in a Critically Ill Patient With Legionella Pneumonia After Extracorporeal Membrane Oxygenation Treatment: Case Report and Literature Review.Front Med (Lausanne). 2021 Jun 30;8:686512. doi: 10.3389/fmed.2021.686512. eCollection 2021. Front Med (Lausanne). 2021. PMID: 34277662 Free PMC article. Review.
References
-
- Zhang J, Gao L, Zhu C, Jin J, Song C, Dong H, et al. . Clinical value of metagenomic next-generation sequencing by Illumina and Nanopore for the detection of pathogens in bronchoalveolar lavage fluid in suspected community-acquired pneumonia patients. Front Cell Infect Microbiol. (2022) 12:1021320. doi: 10.3389/fcimb.2022.1021320, PMID: - DOI - PMC - PubMed
Publication types
Grants and funding
LinkOut - more resources
Full Text Sources
Miscellaneous