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Review
. 2024 Mar 24:18:11795468241239542.
doi: 10.1177/11795468241239542. eCollection 2024.

Impact of Hyperuricemia and Urate-Lowering Agents on Cardiovascular Diseases

Franklin Sosa  1 , Mohammed Shaban  1 , Jose Lopez  2 , Gustavo J Duarte  3 , Swati Jain  4 , Asma Khizar  4 , Timothy Vittorio  1 , Rishabh Mishra  4 , Miguel Rodriguez Guerra  4
Affiliations
Review

Impact of Hyperuricemia and Urate-Lowering Agents on Cardiovascular Diseases

Franklin Sosa et al. Clin Med Insights Cardiol. .

Abstract

The association between hyperuricemia and cardiovascular diseases has been studied for many years. Research has shown a link between high uric acid levels and increased risk of including coronary artery disease hypertension and other cardiovascular conditions. Urate-lowering therapy, particularly with xanthine oxidase inhibitors like allopurinol, has shown promising results in reducing blood pressure in individuals with hyperuricemia and hypertension. Clinical trials and studies have demonstrated significant reductions in both systolic and diastolic blood pressure with urate-lowering treatment. Urate-lowering treatment has shown a favorable effect on reducing systolic blood pressure and major adverse cardiovascular events in patients with previous cardiovascular disease. In terms of cardiovascular safety, clinical trials have indicated that xanthine oxidase inhibitors such as febuxostat are non-inferior to allopurinol and do not increase the risk of death or serious adverse events. Overall, these findings highlight the importance of managing hyperuricemia and utilizing urate-lowering therapy to mitigate the adverse cardiovascular effects associated with elevated uric acid levels.

Keywords: Hyperuricemia; allopurinol; cardiovascular diseases; coronary artery disease; febuxostat; hypertension; uric acid; xanthine oxidase.

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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References

    1. Mahomed FA. On Chronic Bright’s disease, and its essential symptoms. Lancet. 1879;113:46-47.
    1. Gertler MM, Garn SM, Levine SA. Serum uric acid in relation to age and physique in health and in coronary heart disease. Ann Intern Med. 1951;34:1421-1431. - PubMed
    1. Ndrepepa G. Uric acid and cardiovascular disease. Clin Chim Acta. 2018;484:150-163. - PubMed
    1. Colantonio LD, Saag KG, Singh JA, et al.. Gout is associated with an increased risk for incident heart failure among older adults: the REasons for geographic and racial differences in stroke (REGARDS) cohort study. Arthritis Res Ther. 2020;22:86. - PMC - PubMed
    1. Brook RD, Yalavarthi S, Myles JD, et al.. Determinants of vascular function in patients with chronic gout. J Clin Hypertens. 2011;13:178-188. - PMC - PubMed

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