Multilocus linkage analysis in humans: detection of linkage and estimation of recombination

. 1985 May;37(3):482-98.

Multilocus linkage analysis in humans: detection of linkage and estimation of recombination

G M Lathrop, J M Lalouel, C Julier, J Ott

PMID: 3859205
PMCID: PMC1684598

Multilocus linkage analysis in humans: detection of linkage and estimation of recombination

G M Lathrop et al. Am J Hum Genet. 1985 May.

. 1985 May;37(3):482-98.

Authors

G M Lathrop, J M Lalouel, C Julier, J Ott

PMID: 3859205
PMCID: PMC1684598

Abstract

Multilocus linkage analysis is investigated from the viewpoint of the efficiency of recombination estimates under different strategies for detecting linkage and determining gene order within a linkage group. We consider the appropriateness of assuming no interference with data available in human genetic studies. Examples are given to show the significance of multilocus analysis in humans. A computer program package, LINKAGE, for multilocus linkage analysis is described.

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References

1. Am J Hum Genet. 1980 May;32(3):314-31 - PubMed
1. Hum Hered. 1971;21(6):523-42 - PubMed
1. Proc Natl Acad Sci U S A. 1984 Jun;81(11):3443-6 - PubMed
1. Hum Hered. 1975;25(2):95-105 - PubMed
1. Ann Hum Genet. 1976 Nov;40(2):147-63 - PubMed

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[1] Am J Hum Genet. 1980 May;32(3):314-31 - PubMed

[2] Am J Hum Genet. 1980 May;32(3):314-31 - PubMed

[3] Hum Hered. 1971;21(6):523-42 - PubMed

[4] Hum Hered. 1971;21(6):523-42 - PubMed

[5] Proc Natl Acad Sci U S A. 1984 Jun;81(11):3443-6 - PubMed

[6] Proc Natl Acad Sci U S A. 1984 Jun;81(11):3443-6 - PubMed

[7] Hum Hered. 1975;25(2):95-105 - PubMed

[8] Hum Hered. 1975;25(2):95-105 - PubMed

[9] Ann Hum Genet. 1976 Nov;40(2):147-63 - PubMed

[10] Ann Hum Genet. 1976 Nov;40(2):147-63 - PubMed

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Multilocus linkage analysis in humans: detection of linkage and estimation of recombination

Multilocus linkage analysis in humans: detection of linkage and estimation of recombination

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