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Review
. 2024 Mar 25;13(7):992.
doi: 10.3390/foods13070992.

Reactive Carbonyl Species Scavenger: Epigallocatechin-3-Gallate

Haiying Luo  1 , Juanying Ou  1 , Junqing Huang  2
Affiliations
Review

Reactive Carbonyl Species Scavenger: Epigallocatechin-3-Gallate

Haiying Luo et al. Foods. .

Abstract

Epigallocatechin-3-gallate (EGCG), a prominent polyphenol found abundantly in tea, has garnered significant attention for its potential in preventing and ameliorating a wide range of diseases. Its remarkable antioxidant properties and ability to capture reactive carbonyl species make it a key player among tea's polyphenolic components. This paper delves into the synthesis and origins of both EGCG and reactive carbonyl species (RCS), emphasizing the toxicity of RCS in various food sources and their formation during food processing. Understanding EGCG's capability to capture and metabolize RCS is crucial for harnessing its health benefits. Thus, this paper explores the underlying mechanisms of EGCG for RCS inhibition and its role in capturing these compounds to generate EGCG-RCS adducts. And the absorption and metabolism of EGCG-RCS adducts is also discussed.

Keywords: adduct; epigallocatechin-3-gallate; polyphenols; reactive carbonyl species.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
RCS and the by-products of RCS are highly reactive with cellular components and exhibit toxicity. The toxicity involves multiple systems and organs (↑ indicates an increase in a certain indicator; ↓ indicates a decrease in a certain indicator).
Figure 2
Figure 2
The source of reactive carbonyl species (RCS) from foods mainly including: natural foods without food processing, fermentation, lipids oxidation, Maillard reaction, and endogenous amino acid metabolism.
Figure 3
Figure 3
Key links affecting RCS metabolism can be divided into endogenous factors and exogenous factors. Endogenous factors mainly rely on carnosine and enzymes; during the exogenous metabolic process, dietary phenolic compounds are considered to be major RCS scavengers.
Figure 4
Figure 4
The main adduct of EGCG with MDA, MGO, ACR, and HNE, the main absorption metabolic pathway of the adduct in vivo.
See this image and copyright information in PMC

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